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High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
Zhao Y, Du X, Duan Y, Pan X, Sun Y, You T, Han L, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L, Zhang L, Rao Z, Yang H. Zhao Y, et al. Among authors: guo h. Protein Cell. 2021 Nov;12(11):877-888. doi: 10.1007/s13238-021-00836-9. Epub 2021 Apr 17. Protein Cell. 2021. PMID: 33864621 Free PMC article.
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Li T, Han X, Gu C, Guo H, Zhang H, Wang Y, Hu C, Wang K, Liu F, Luo F, Zhang Y, Hu J, Wang W, Li S, Hao Y, Shen M, Huang J, Long Y, Song S, Wu R, Mu S, Chen Q, Gao F, Wang J, Long S, Li L, Wu Y, Gao Y, Xu W, Cai X, Qu D, Zhang Z, Zhang H, Li N, Gao Q, Zhang G, He C, Wang W, Ji X, Tang N, Yuan Z, Xie Y, Yang H, Zhang B, Huang A, Jin A. Li T, et al. Among authors: guo h. Nat Commun. 2021 Nov 2;12(1):6304. doi: 10.1038/s41467-021-26539-7. Nat Commun. 2021. PMID: 34728625 Free PMC article.
A core epitope targeting antibody of SARS-CoV-2.
Zhao S, Liu F, Qiu S, Lan Q, Wu Y, Xu W, Ke J, Yang J, Liu X, Wang K, Guo H, Xia S, Zhang F, Wang J, Hu X, Lu L, Jiang S, Zhao S, Liu L, Xie Y, Yang X, Wang H, Zhong G. Zhao S, et al. Among authors: guo h. Protein Cell. 2022 Oct 26;14(1):74-78. doi: 10.1093/procel/pwac042. eCollection 2023 Jan. Protein Cell. 2022. PMID: 36726762 Free PMC article. No abstract available.
Mechanism of an RBM-targeted rabbit monoclonal antibody 9H1 neutralizing SARS-CoV-2.
Chu X, Ding X, Yang Y, Lu Y, Li T, Gao Y, Zheng L, Xiao H, Yang T, Cheng H, Huang H, Liu Y, Lou Y, Wu C, Chen Y, Yang H, Ji X, Guo H. Chu X, et al. Among authors: guo h. Biochem Biophys Res Commun. 2023 Jun 11;660:43-49. doi: 10.1016/j.bbrc.2023.04.002. Epub 2023 Apr 5. Biochem Biophys Res Commun. 2023. PMID: 37062240 Free PMC article.
Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Guo Y, Zhang G, Yang Q, Xie X, Lu Y, Cheng X, Wang H, Liang J, Tang J, Gao Y, Shang H, Dai J, Shi Y, Zhou J, Zhou J, Guo H, Yang H, Qi J, Liu L, Ma S, Zhang B, Huo Q, Xie Y, Wu J, Dong F, Zhang S, Lou Z, Gao Y, Song Z, Wang W, Sun Z, Yang X, Xiong D, Liu F, Chen X, Zhu P, Wang X, Cheng T, Rao Z. Guo Y, et al. Among authors: guo h. Nat Commun. 2023 Jun 15;14(1):3537. doi: 10.1038/s41467-023-39267-x. Nat Commun. 2023. PMID: 37322000 Free PMC article.
Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron.
Zhang X, Luo F, Zhang H, Guo H, Zhou J, Li T, Chen S, Song S, Shen M, Wu Y, Gao Y, Han X, Wang Y, Hu C, Zhao X, Guo H, Zhang D, Lu Y, Wang W, Wang K, Tang N, Jin T, Ding M, Luo S, Lin C, Lu T, Lu B, Tian Y, Yang C, Cheng G, Yang H, Jin A, Ji X, Gong R, Chiu S, Huang A. Zhang X, et al. Among authors: guo h. JCI Insight. 2024 Apr 8;9(7):e171034. doi: 10.1172/jci.insight.171034. JCI Insight. 2024. PMID: 38587080 Free article.
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