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Covalent inhibition of pro-apoptotic BAX.
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. McHenry MW, et al. Among authors: gygi ma, gygi sp. Nat Chem Biol. 2024 Jan 17. doi: 10.1038/s41589-023-01537-6. Online ahead of print. Nat Chem Biol. 2024. PMID: 38233584
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW. Ordureau A, et al. Among authors: gygi sp. Mol Cell. 2014 Nov 6;56(3):360-375. doi: 10.1016/j.molcel.2014.09.007. Epub 2014 Oct 2. Mol Cell. 2014. PMID: 25284222 Free PMC article.
Tissue-Specific Oncogenic Activity of KRASA146T.
Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. Poulin EJ, et al. Among authors: gygi sp. Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5. Cancer Discov. 2019. PMID: 30952657 Free PMC article.
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Hauseman ZJ, et al. Among authors: gygi sp. Mol Cell. 2020 Jul 2;79(1):68-83.e7. doi: 10.1016/j.molcel.2020.05.029. Epub 2020 Jun 12. Mol Cell. 2020. PMID: 32533918 Free PMC article.
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.
Bennett CF, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P. Bennett CF, et al. Among authors: gygi sp. Nat Chem Biol. 2021 Jun;17(6):703-710. doi: 10.1038/s41589-021-00772-z. Epub 2021 Mar 15. Nat Chem Biol. 2021. PMID: 33723432 Free PMC article.
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD. Prew MS, et al. Among authors: gygi sp. Cell Rep. 2022 Oct 4;41(1):111445. doi: 10.1016/j.celrep.2022.111445. Cell Rep. 2022. PMID: 36198266 Free PMC article.
699 results