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2001 1
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Page 1
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.
Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Connolly NMC, et al. Among authors: dussmann h. Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Cell Death Differ. 2018. PMID: 29229998 Free PMC article. Review.
In this consensus article, we collate details on and discuss pitfalls of existing experimental approaches to assess mitochondrial function in in vitro cellular models of neurodegenerative diseases, including specific protocols for the measurement of oxygen consumption rate in pri …
In this consensus article, we collate details on and discuss pitfalls of existing experimental approaches to assess mitochondrial function i …
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome.
Duggan WP, Salvucci M, Kisakol B, Lindner AU, Reynolds IS, Dussmann H, Fay J, O'Grady T, Longley DB, Ginty F, Mc Donough E, Slade DJ, Burke JP, Prehn JHM. Duggan WP, et al. Among authors: dussmann h. J Mol Med (Berl). 2023 Jul;101(7):829-841. doi: 10.1007/s00109-023-02324-5. Epub 2023 May 12. J Mol Med (Berl). 2023. PMID: 37171483 Free PMC article.
BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study.
Lucantoni F, Salvucci M, Düssmann H, Lindner AU, Lambrechts D, Prehn JHM. Lucantoni F, et al. Among authors: dussmann h. Cell Death Differ. 2021 May;28(5):1512-1531. doi: 10.1038/s41418-020-00683-x. Epub 2020 Dec 16. Cell Death Differ. 2021. PMID: 33328572 Free PMC article.
We found that BCL2 and BCL(X)L increase the metabolic robustness of MCF7 cells, and that this was associated with increased mitochondrial NAD(P)H and ATP levels. Experiments with the F(1)F(0) synthase inhibitor oligomycin demonstrated that BCL2 and in particular BCL(X)L, w …
We found that BCL2 and BCL(X)L increase the metabolic robustness of MCF7 cells, and that this was associated with increased mitochondrial NA …
Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.
Lucantoni F, Lindner AU, O'Donovan N, Düssmann H, Prehn JHM. Lucantoni F, et al. Among authors: dussmann h. Cell Death Dis. 2018 Jan 19;9(2):42. doi: 10.1038/s41419-017-0039-y. Cell Death Dis. 2018. PMID: 29352235 Free PMC article.
Using absolute protein levels of BAX, BAK, BCL2, BCL(X)L and MCL1 as input for DR_MOMP, we found a strong correlation between model predictions and responses of a panel of TNBC cells to 24 and 48 h cisplatin (R(2) = 0.96 and 0.95, respectively) and paclitaxel treatments (R …
Using absolute protein levels of BAX, BAK, BCL2, BCL(X)L and MCL1 as input for DR_MOMP, we found a strong correlation between model predicti …
Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells.
Glunde K, Düssmann H, Juretschke HP, Leibfritz D. Glunde K, et al. Among authors: dussmann h. J Neurochem. 2002 Jan;80(1):36-44. doi: 10.1046/j.0022-3042.2001.00661.x. J Neurochem. 2002. PMID: 11796741 Free article.
The role of Na(+)/H(+) exchange subtype 1 was investigated during extracellular acidification and subsequent pH recovery in the absence and presence of (4-isopropyl-3-methylsulphonyl-benzoyl)-guanidine methanesulfonate (HOE642, Cariporid), a new selective and powerful inhi …
The role of Na(+)/H(+) exchange subtype 1 was investigated during extracellular acidification and subsequent pH recovery in the absen …
AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.
Anilkumar U, Weisová P, Düssmann H, Concannon CG, König HG, Prehn JH. Anilkumar U, et al. Among authors: dussmann h. J Neurochem. 2013 Mar;124(5):721-34. doi: 10.1111/jnc.12108. Epub 2012 Dec 26. J Neurochem. 2013. PMID: 23199202 Free article.
Activation of AMPK with low concentrations of AICAR (0.1 mM for 2 h) induced a transient increase in AMPK phosphorylation, protecting neurons against NMDA-induced excitotoxicity. ...
Activation of AMPK with low concentrations of AICAR (0.1 mM for 2 h) induced a transient increase in AMPK phosphorylation, protecting …
Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.
Wobser H, Düssmann H, Kögel D, Wang H, Reimertz C, Wollheim CB, Byrne MM, Prehn JH. Wobser H, et al. Among authors: dussmann h. J Biol Chem. 2002 Feb 22;277(8):6413-21. doi: 10.1074/jbc.M108390200. Epub 2001 Nov 27. J Biol Chem. 2002. PMID: 11724785 Free article.
We investigated the involvement of apoptotic events in INS-1 insulinoma cells overexpressing wild-type HNF-1 alpha (WT-HNF-1 alpha) or a dominant-negative mutant (DN-HNF-1 alpha) under control of a doxycycline-dependent transcriptional activator. Forty-eight h after induct …
We investigated the involvement of apoptotic events in INS-1 insulinoma cells overexpressing wild-type HNF-1 alpha (WT-HNF-1 alpha) or a dom …
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K. Prinz H, et al. Among authors: dussmann h. J Med Chem. 2003 Jul 17;46(15):3382-94. doi: 10.1021/jm0307685. J Med Chem. 2003. PMID: 12852768
In general, the antiproliferative activity correlated with inhibition of tubulin polymerization. The most active compounds strongly displaced [(3)H]colchicine from its binding site in the tubulin, yielding IC(50) values 3- to 4-fold lower than that of colchicine. ...
In general, the antiproliferative activity correlated with inhibition of tubulin polymerization. The most active compounds strongly displace …