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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.
Chandra SM, Razavi H, Kim J, Agrawal R, Kundu RK, de Jesus Perez V, Zamanian RT, Quertermous T, Chun HJ. Chandra SM, et al. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):814-20. doi: 10.1161/ATVBAHA.110.219980. Epub 2011 Jan 13. Arterioscler Thromb Vasc Biol. 2011. PMID: 21233449 Free PMC article.
Apelin is necessary for the maintenance of insulin sensitivity.
Yue P, Jin H, Aillaud M, Deng AC, Azuma J, Asagami T, Kundu RK, Reaven GM, Quertermous T, Tsao PS. Yue P, et al. Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E59-67. doi: 10.1152/ajpendo.00385.2009. Epub 2009 Oct 27. Am J Physiol Endocrinol Metab. 2010. PMID: 19861585 Free PMC article.
Endogenous regulation of cardiovascular function by apelin-APJ.
Charo DN, Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, Ho YD, Chun HJ, Bernstein D, Ashley EA, Quertermous T. Charo DN, et al. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1904-13. doi: 10.1152/ajpheart.00686.2009. Epub 2009 Sep 18. Am J Physiol Heart Circ Physiol. 2009. PMID: 19767528 Free PMC article.
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation.
Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL, Quertermous T. Leeper NJ, et al. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1329-35. doi: 10.1152/ajpheart.01341.2008. Epub 2009 Mar 20. Am J Physiol Heart Circ Physiol. 2009. PMID: 19304942 Free PMC article.
In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure.
Sheikh AY, Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D, Hendry SL, Wagner RA, Chen MM, Ali ZA, Yue P, Huynh DT, Connolly AJ, Pelletier MP, Tsao PS, Robbins RC, Quertermous T. Sheikh AY, et al. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H88-98. doi: 10.1152/ajpheart.00935.2007. Epub 2007 Sep 28. Am J Physiol Heart Circ Physiol. 2008. PMID: 17906101 Free PMC article.