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Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops.
Schmidt AE, Padmanabhan K, Underwood MC, Bode W, Mather T, Bajaj SP. Schmidt AE, et al. J Biol Chem. 2002 Aug 9;277(32):28987-95. doi: 10.1074/jbc.M201892200. Epub 2002 May 23. J Biol Chem. 2002. PMID: 12029084 Free article.
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