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Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.
Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J. Hewitt T, et al. Among authors: haggarty sj. Mol Psychiatry. 2023 Dec;28(12):5237-5250. doi: 10.1038/s41380-023-02152-6. Epub 2023 Jul 4. Mol Psychiatry. 2023. PMID: 37402854 Free PMC article.
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. Pao PC, et al. Among authors: haggarty sj. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120. doi: 10.1073/pnas.2217864120. Epub 2023 Apr 12. Proc Natl Acad Sci U S A. 2023. PMID: 37043533 Free PMC article.
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.
Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD 4th, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, Wei J, Young DW, Akella LB, Ross NT, Zhang YL, Fass DM, Reis SA, Zhao WN, Haggarty SJ, Palmer M, Foley MA. Marcaurelle LA, et al. Among authors: haggarty sj. J Am Chem Soc. 2010 Dec 1;132(47):16962-76. doi: 10.1021/ja105119r. Epub 2010 Nov 10. J Am Chem Soc. 2010. PMID: 21067169 Free PMC article.
An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. Gräff J, et al. Among authors: haggarty sj. Nature. 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849. Nature. 2012. PMID: 22388814 Free PMC article.
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.
Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Fass DM, et al. Among authors: haggarty sj. Neuropharmacology. 2013 Jan;64:81-96. doi: 10.1016/j.neuropharm.2012.06.043. Epub 2012 Jul 4. Neuropharmacology. 2013. PMID: 22771460 Free PMC article.
Epigenetic mechanisms in mood disorders: targeting neuroplasticity.
Fass DM, Schroeder FA, Perlis RH, Haggarty SJ. Fass DM, et al. Among authors: haggarty sj. Neuroscience. 2014 Apr 4;264:112-30. doi: 10.1016/j.neuroscience.2013.01.041. Epub 2013 Jan 30. Neuroscience. 2014. PMID: 23376737 Free PMC article. Review.
165 results