Hajicek N - Search Results

1

Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.

Kozasa T, Hajicek N, Chow CR, Suzuki N. Kozasa T, et al. Among authors: hajicek n. J Biochem. 2011 Oct;150(4):357-69. doi: 10.1093/jb/mvr105. Epub 2011 Aug 26. J Biochem. 2011. PMID: 21873336 Free PMC article. Review.

2

Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.

Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokita R, Minami S, Kodama T, Hamakubo T, Kozasa T. Suzuki N, et al. Among authors: hajicek n. J Biol Chem. 2009 Feb 20;284(8):5000-9. doi: 10.1074/jbc.M804073200. Epub 2008 Dec 12. J Biol Chem. 2009. PMID: 19074425 Free PMC article.

3

Regulation and physiological functions of G12/13-mediated signaling pathways.

Suzuki N, Hajicek N, Kozasa T. Suzuki N, et al. Among authors: hajicek n. Neurosignals. 2009;17(1):55-70. doi: 10.1159/000186690. Epub 2009 Feb 12. Neurosignals. 2009. PMID: 19212140 Free PMC article. Review.

4

Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.

Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T. Hajicek N, et al. J Biol Chem. 2011 Jun 10;286(23):20625-36. doi: 10.1074/jbc.M110.201392. Epub 2011 Apr 20. J Biol Chem. 2011. PMID: 21507947 Free PMC article.

5

Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs.

Kreutz B, Hajicek N, Yau DM, Nakamura S, Kozasa T. Kreutz B, et al. Among authors: hajicek n. Cell Signal. 2007 Aug;19(8):1681-9. doi: 10.1016/j.cellsig.2007.03.004. Epub 2007 Mar 15. Cell Signal. 2007. PMID: 17449226

6

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.

Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Jernigan KK, et al. Among authors: hajicek n. Sci Signal. 2010 May 11;3(121):ra37. doi: 10.1126/scisignal.2000647. Sci Signal. 2010. PMID: 20460648 Free PMC article.

7

A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes.

Huang W, Carr AJ, Hajicek N, Sokolovski M, Siraliev-Perez E, Hardy PB, Pearce KH, Sondek J, Zhang Q. Huang W, et al. Among authors: hajicek n. Biochemistry. 2020 Oct 20;59(41):4029-4038. doi: 10.1021/acs.biochem.0c00511. Epub 2020 Oct 7. Biochemistry. 2020. PMID: 33028071 Free PMC article.

8

Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes.

Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek J. Hajicek N, et al. Biochemistry. 2013 Jul 16;52(28):4810-9. doi: 10.1021/bi400433b. Epub 2013 Jul 9. Biochemistry. 2013. PMID: 23777354 Free PMC article.

9

A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes.

Huang W, Wang X, Endo-Streeter S, Barrett M, Waybright J, Wohlfeld C, Hajicek N, Harden TK, Sondek J, Zhang Q. Huang W, et al. Among authors: hajicek n. J Biol Chem. 2018 Feb 2;293(5):1728-1735. doi: 10.1074/jbc.RA117.000926. Epub 2017 Dec 20. J Biol Chem. 2018. PMID: 29263090 Free PMC article.

10

Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q. Huang W, et al. Among authors: hajicek n. J Biol Chem. 2013 Feb 22;288(8):5840-8. doi: 10.1074/jbc.M112.422501. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23297405 Free PMC article.

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