Hall BS - Search Results

1

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.

Ogbechi J, Ruf MT, Hall BS, Bodman-Smith K, Vogel M, Wu HL, Stainer A, Esmon CT, Ahnström J, Pluschke G, Simmonds RE. Ogbechi J, et al. Among authors: hall bs. PLoS Pathog. 2015 Jul 16;11(7):e1005011. doi: 10.1371/journal.ppat.1005011. eCollection 2015 Jul. PLoS Pathog. 2015. PMID: 26181660 Free PMC article.

2

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.

Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE. Hall BS, et al. PLoS Pathog. 2014 Apr 3;10(4):e1004061. doi: 10.1371/journal.ppat.1004061. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24699819 Free PMC article.

3

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.

Hall BS, Dos Santos SJ, Hsieh LT, Manifava M, Ruf MT, Pluschke G, Ktistakis N, Simmonds RE. Hall BS, et al. Autophagy. 2022 Apr;18(4):841-859. doi: 10.1080/15548627.2021.1961067. Epub 2021 Aug 23. Autophagy. 2022. PMID: 34424124 Free PMC article.

4

Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.

Hsieh LT, Dos Santos SJ, Hall BS, Ogbechi J, Loglo AD, Salguero FJ, Ruf MT, Pluschke G, Simmonds RE. Hsieh LT, et al. Among authors: hall bs. PLoS Pathog. 2022 Jan 31;18(1):e1010280. doi: 10.1371/journal.ppat.1010280. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35100311 Free PMC article. Clinical Trial.

5

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer.

Hall BS, Hsieh LT, Sacre S, Simmonds RE. Hall BS, et al. Front Immunol. 2022 Jan 26;12:788146. doi: 10.3389/fimmu.2021.788146. eCollection 2021. Front Immunol. 2022. PMID: 35154073 Free PMC article.

6

Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.

Hall B, Simmonds R. Hall B, et al. Biochem Soc Trans. 2014 Feb;42(1):177-83. doi: 10.1042/BST20130133. Biochem Soc Trans. 2014. PMID: 24450648 Free article. Review.

7

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.

Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE. Ogbechi J, et al. Among authors: hall bs. Cell Death Dis. 2018 Mar 14;9(3):397. doi: 10.1038/s41419-018-0427-y. Cell Death Dis. 2018. PMID: 29540678 Free PMC article.

8

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state.

Bhadra P, Dos Santos S, Gamayun I, Pick T, Neumann C, Ogbechi J, Hall BS, Zimmermann R, Helms V, Simmonds RE, Cavalié A. Bhadra P, et al. Among authors: hall bs. Biochem J. 2021 Nov 26;478(22):4005-4024. doi: 10.1042/BCJ20210345. Biochem J. 2021. PMID: 34726690 Free PMC article.

9

Structure of the Inhibited State of the Sec Translocon.

Gérard SF, Hall BS, Zaki AM, Corfield KA, Mayerhofer PU, Costa C, Whelligan DK, Biggin PC, Simmonds RE, Higgins MK. Gérard SF, et al. Among authors: hall bs. Mol Cell. 2020 Aug 6;79(3):406-415.e7. doi: 10.1016/j.molcel.2020.06.013. Epub 2020 Jul 9. Mol Cell. 2020. PMID: 32692975 Free PMC article.

10

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F.

O'Keefe S, Bhadra P, Duah KB, Zong G, Tenay L, Andrews L, Schneider H, Anderson A, Hu Z, Aljewari HS, Hall BS, Simmonds RE, Helms V, High S, Shi WQ. O'Keefe S, et al. Among authors: hall bs. Molecules. 2022 Jul 10;27(14):4419. doi: 10.3390/molecules27144419. Molecules. 2022. PMID: 35889292 Free PMC article.

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