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LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Zuo Y, He J, Liu S, Xu Y, Liu J, Qiao C, Zang L, Sun W, Yuan Y, Zhang H, Chen X, Jin L, Miao Y, Huang F, Ren T, Wang J, Qian F, Zhu C, Zhang W, Liu Y, Xu G, Ma F, Zheng H. Zuo Y, et al. Among authors: he j. Sci Adv. 2022 Apr 8;8(14):eabj3887. doi: 10.1126/sciadv.abj3887. Epub 2022 Apr 8. Sci Adv. 2022. PMID: 35394840 Free PMC article.
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Zhang HG, Guo J, Yuan Y, Zuo Y, Liu J, Zhu L, Miao Y, Chen X, Jin L, Huang F, Ren T, He J, Shi W, Wen Z, Zhu C, Zheng H, Dong C, Qian F. Zhang HG, et al. Among authors: he j. Front Microbiol. 2020 Nov 19;11:597972. doi: 10.3389/fmicb.2020.597972. eCollection 2020. Front Microbiol. 2020. PMID: 33329486 Free PMC article.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J. Chen X, et al. Among authors: he j. Immunology. 2021 Jul;163(3):278-292. doi: 10.1111/imm.13315. Epub 2021 Feb 22. Immunology. 2021. PMID: 33513265 Free PMC article.
A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis.
Chen X, Wu Q, Gong Z, Ren T, Du Q, Yuan Y, Zuo Y, Miao Y, He J, Qiao C, Zheng Z, Zhang T, Huang L, Xie Z, Wang J, Zhu Y, Zhu C, Xu Y, Wu D, Gong F, Cheng J, Wen C, Zheng H. Chen X, et al. Among authors: he j. J Nat Prod. 2022 Apr 22;85(4):1109-1117. doi: 10.1021/acs.jnatprod.1c01231. Epub 2022 Mar 18. J Nat Prod. 2022. PMID: 35302365 Review.
E3 ubiquitin ligase MID1 ubiquitinates and degrades type-I interferon receptor 2.
Chen X, Zhao Q, Xu Y, Wu Q, Zhang R, Du Q, Miao Y, Zuo Y, Zhang HG, Huang F, Ren T, He J, Qiao C, Li Y, Li S, Xu Y, Wu D, Yu Z, Lv H, Wang J, Zheng H, Yuan Y. Chen X, et al. Among authors: he j. Immunology. 2022 Nov;167(3):398-412. doi: 10.1111/imm.13544. Epub 2022 Jul 23. Immunology. 2022. PMID: 35794827 Free article.
Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis.
Chen X, Wu Q, Cao X, Yang Y, Gong Z, Ren T, Du Q, Yuan Y, Zuo Y, Miao Y, He J, Qiao C, Zheng Z, Zhang T, Xu Y, Wu D, Wang Q, Huang L, Xie Z, Lv H, Wang J, Gong F, Liu Z, Wen C, Zheng H. Chen X, et al. Among authors: he j. Int Immunopharmacol. 2022 Nov;112:109228. doi: 10.1016/j.intimp.2022.109228. Epub 2022 Sep 9. Int Immunopharmacol. 2022. PMID: 36095947
Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 infection.
Zuo Y, Zheng Z, Huang Y, He J, Zang L, Ren T, Cao X, Miao Y, Yuan Y, Liu Y, Ma F, Dai J, Tian S, Ding Q, Zheng H. Zuo Y, et al. Among authors: he j. EMBO Rep. 2023 Apr 5;24(4):e56374. doi: 10.15252/embr.202256374. Epub 2023 Mar 6. EMBO Rep. 2023. PMID: 36876523 Free PMC article.
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