Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.
Xu Y, Jiang YQ, Li C, He M, Rusyniak WG, Annamdevula N, Ochoa J, Leavesley SJ, Xu J, Rich TC, Lin MT, Zha XM.
Xu Y, et al. Among authors: he m.
FASEB J. 2018 Jul;32(7):3832-3843. doi: 10.1096/fj.201701367R. Epub 2018 Feb 15.
FASEB J. 2018.
PMID: 29447005
Free PMC article.
These data suggest that ASICs are likely to have a larger impact on acidosis-induced neuronal injuries in humans than mice, and this effect is, at least in part, a result of more efficient trafficking of hASIC1a.-Xu, Y., Jiang, Y.-Q., Li, C., He, M., Rusyniak, W. G. …
These data suggest that ASICs are likely to have a larger impact on acidosis-induced neuronal injuries in humans than mice, and this effect …