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Complexity of macrophage metabolism in infection.
He W, Heinz A, Jahn D, Hiller K. He W, et al. Curr Opin Biotechnol. 2021 Apr;68:231-239. doi: 10.1016/j.copbio.2021.01.020. Epub 2021 Feb 18. Curr Opin Biotechnol. 2021. PMID: 33610128 Review.
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. He W, et al. Nat Metab. 2022 May;4(5):524-533. doi: 10.1038/s42255-022-00565-1. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655024 Free PMC article.
Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2.
Heinz A, Nonnenmacher Y, Henne A, Khalil MA, Bejkollari K, Dostert C, Hosseini S, Goldmann O, He W, Palorini R, Verschueren C, Korte M, Chiaradonna F, Medina E, Brenner D, Hiller K. Heinz A, et al. Among authors: he w. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166530. doi: 10.1016/j.bbadis.2022.166530. Epub 2022 Aug 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 36038039 Free article.
BCAT1 redox function maintains mitotic fidelity.
Francois L, Boskovic P, Knerr J, He W, Sigismondo G, Schwan C, More TH, Schlotter M, Conway ME, Krijgsveld J, Hiller K, Grosse R, Lichter P, Radlwimmer B. Francois L, et al. Among authors: he w. Cell Rep. 2022 Oct 18;41(3):111524. doi: 10.1016/j.celrep.2022.111524. Cell Rep. 2022. PMID: 36260995 Free article.
TLR4 triggered complex inflammation in human pancreatic islets.
He W, Rebello O, Savino R, Terracciano R, Schuster-Klein C, Guardiola B, Maedler K. He W, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):86-97. doi: 10.1016/j.bbadis.2018.09.030. Epub 2018 Oct 1. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30287405 Free article.
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