Heasley LE - Search Results

1

Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.

Kim J, Vasu VT, Mishra R, Singleton KR, Yoo M, Leach SM, Farias-Hesson E, Mason RJ, Kang J, Ramamoorthy P, Kern JA, Heasley LE, Finigan JH, Tan AC. Kim J, et al. Among authors: heasley le. Bioinformatics. 2014 Sep 1;30(17):2393-8. doi: 10.1093/bioinformatics/btu323. Epub 2014 May 7. Bioinformatics. 2014. PMID: 24812339 Free PMC article.

2

Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.

Soriano AF, Helfrich B, Chan DC, Heasley LE, Bunn PA Jr, Chou TC. Soriano AF, et al. Among authors: heasley le. Cancer Res. 1999 Dec 15;59(24):6178-84. Cancer Res. 1999. PMID: 10626810

3

Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells.

Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA Jr, Heasley LE. Marek L, et al. Among authors: heasley le. Mol Pharmacol. 2009 Jan;75(1):196-207. doi: 10.1124/mol.108.049544. Epub 2008 Oct 10. Mol Pharmacol. 2009. PMID: 18849352 Free PMC article.

4

The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer.

Kono SA, Marshall ME, Ware KE, Heasley LE. Kono SA, et al. Among authors: heasley le. Drug Resist Updat. 2009 Aug-Oct;12(4-5):95-102. doi: 10.1016/j.drup.2009.05.001. Epub 2009 Jun 4. Drug Resist Updat. 2009. PMID: 19501013 Free PMC article. Review.

5

Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.

Ware KE, Marshall ME, Heasley LR, Marek L, Hinz TK, Hercule P, Helfrich BA, Doebele RC, Heasley LE. Ware KE, et al. Among authors: heasley lr, heasley le. PLoS One. 2010 Nov 29;5(11):e14117. doi: 10.1371/journal.pone.0014117. PLoS One. 2010. PMID: 21152424 Free PMC article.

6

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.

Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA, Reyland ME. Symonds JM, et al. Among authors: heasley le. Cancer Res. 2011 Mar 15;71(6):2087-97. doi: 10.1158/0008-5472.CAN-10-1511. Epub 2011 Feb 18. Cancer Res. 2011. PMID: 21335545 Free PMC article.

7

Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells.

Marshall ME, Hinz TK, Kono SA, Singleton KR, Bichon B, Ware KE, Marek L, Frederick BA, Raben D, Heasley LE. Marshall ME, et al. Among authors: heasley le. Clin Cancer Res. 2011 Aug 1;17(15):5016-25. doi: 10.1158/1078-0432.CCR-11-0050. Epub 2011 Jun 14. Clin Cancer Res. 2011. PMID: 21673064 Free PMC article.

8

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ, Kondo KL, Linderman DJ, Heasley LE, Franklin WA, Varella-Garcia M, Camidge DR. Doebele RC, et al. Among authors: le at, heasley le. Clin Cancer Res. 2012 Mar 1;18(5):1472-82. doi: 10.1158/1078-0432.CCR-11-2906. Epub 2012 Jan 10. Clin Cancer Res. 2012. PMID: 22235099 Free PMC article.

9

A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.

Singleton KR, Kim J, Hinz TK, Marek LA, Casás-Selves M, Hatheway C, Tan AC, DeGregori J, Heasley LE. Singleton KR, et al. Among authors: heasley le. Mol Pharmacol. 2013 Apr;83(4):882-93. doi: 10.1124/mol.112.084111. Epub 2013 Jan 31. Mol Pharmacol. 2013. PMID: 23371912 Free PMC article.

10

A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop.

Ware KE, Hinz TK, Kleczko E, Singleton KR, Marek LA, Helfrich BA, Cummings CT, Graham DK, Astling D, Tan AC, Heasley LE. Ware KE, et al. Among authors: heasley le. Oncogenesis. 2013 Mar 25;2(3):e39. doi: 10.1038/oncsis.2013.4. Oncogenesis. 2013. PMID: 23552882 Free PMC article.

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