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The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: insights from type II diabetes.
Annu Rev Biophys. 2009;38:125-52. doi: 10.1146/annurev.biophys.050708.133622.
Annu Rev Biophys. 2009.
PMID: 19416063
Review.
Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide.
Knight JD, Hebda JA, Miranker AD.
Knight JD, et al. Among authors: hebda ja.
Biochemistry. 2006 Aug 8;45(31):9496-508. doi: 10.1021/bi060579z.
Biochemistry. 2006.
PMID: 16878984
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Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide.
Koo BW, Hebda JA, Miranker AD.
Koo BW, et al. Among authors: hebda ja.
Protein Eng Des Sel. 2008 Mar;21(3):147-54. doi: 10.1093/protein/gzm076.
Protein Eng Des Sel. 2008.
PMID: 18299291
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A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.
Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD.
Hebda JA, et al.
Chem Biol. 2009 Sep 25;16(9):943-50. doi: 10.1016/j.chembiol.2009.08.013.
Chem Biol. 2009.
PMID: 19778722
Free PMC article.
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Small molecule screening in context: lipid-catalyzed amyloid formation.
Hebda JA, Magzoub M, Miranker AD.
Hebda JA, et al.
Protein Sci. 2014 Oct;23(10):1341-8. doi: 10.1002/pro.2518. Epub 2014 Jul 28.
Protein Sci. 2014.
PMID: 25043951
Free PMC article.
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Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics.
Kumar S, Schlamadinger DE, Brown MA, Dunn JM, Mercado B, Hebda JA, Saraogi I, Rhoades E, Hamilton AD, Miranker AD.
Kumar S, et al. Among authors: hebda ja.
Chem Biol. 2015 Mar 19;22(3):369-78. doi: 10.1016/j.chembiol.2015.01.006. Epub 2015 Mar 5.
Chem Biol. 2015.
PMID: 25754474
Free PMC article.
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Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.
Saraogi I, Hebda JA, Becerril J, Estroff LA, Miranker AD, Hamilton AD.
Saraogi I, et al. Among authors: hebda ja.
Angew Chem Int Ed Engl. 2010;49(4):736-9. doi: 10.1002/anie.200901694.
Angew Chem Int Ed Engl. 2010.
PMID: 20029853
Free PMC article.
No abstract available.
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