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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.
Gu F, Krüger A, Roggenkamp HG, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C LC, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao JY, Schetelig D, Werner R, Schröder K, Carty M, Bowie AG, Huber S, Meier C, Mittrücker HW, Heeren J, Krause KH, Flügel A, Diercks BP, Guse AH. Gu F, et al. Among authors: heeren j. Sci Signal. 2021 Nov 16;14(709):eabe3800. doi: 10.1126/scisignal.abe3800. Epub 2021 Nov 16. Sci Signal. 2021. PMID: 34784249
CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues.
Benzi A, Sturla L, Heine M, Fischer AW, Spinelli S, Magnone M, Sociali G, Parodi A, Fenoglio D, Emionite L, Koch-Nolte F, Mittrücker HW, Guse AH, De Flora A, Zocchi E, Heeren J, Bruzzone S. Benzi A, et al. Among authors: heeren j. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158819. doi: 10.1016/j.bbalip.2020.158819. Epub 2020 Sep 30. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33010451
Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
Benzi A, Grozio A, Spinelli S, Sturla L, Guse AH, De Flora A, Zocchi E, Heeren J, Bruzzone S. Benzi A, et al. Among authors: heeren j. Nutrients. 2021 Oct 23;13(11):3734. doi: 10.3390/nu13113734. Nutrients. 2021. PMID: 34835990 Free PMC article. Review.
Short-term dietary changes can result in mucosal and systemic immune depression.
Siracusa F, Schaltenberg N, Kumar Y, Lesker TR, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks BP, Bönisch F, Fischer AW, Scognamiglio P, Pauly MJ, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker HW, Kretz O, Guse AH, Izbicki JR, Lassen KG, Strowig T, Schweizer M, Villablanca EJ, Elinav E, Huber S, Heeren J, Gagliani N. Siracusa F, et al. Among authors: heeren j. Nat Immunol. 2023 Sep;24(9):1473-1486. doi: 10.1038/s41590-023-01587-x. Epub 2023 Aug 14. Nat Immunol. 2023. PMID: 37580603 Free PMC article.
The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice.
Benzi A, Heine M, Spinelli S, Salis A, Worthmann A, Diercks B, Astigiano C, Pérez Mato R, Memushaj A, Sturla L, Vellone V, Damonte G, Jaeckstein MY, Koch-Nolte F, Mittrücker HW, Guse AH, De Flora A, Heeren J, Bruzzone S. Benzi A, et al. Among authors: heeren j. Front Endocrinol (Lausanne). 2024 Feb 6;14:1251351. doi: 10.3389/fendo.2023.1251351. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38390373 Free PMC article.
Time-resolved role of P2X4 and P2X7 during CD8+ T cell activation.
Brock VJ, Lory NC, Möckl F, Birus M, Stähler T, Woelk LM, Jaeckstein M, Heeren J, Koch-Nolte F, Rissiek B, Mittrücker HW, Guse AH, Werner R, Diercks BP. Brock VJ, et al. Among authors: heeren j. Front Immunol. 2024 Feb 15;15:1258119. doi: 10.3389/fimmu.2024.1258119. eCollection 2024. Front Immunol. 2024. PMID: 38426095 Free PMC article.
Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.
Carambia A, Freund B, Schwinge D, Bruns OT, Salmen SC, Ittrich H, Reimer R, Heine M, Huber S, Waurisch C, Eychmüller A, Wraith DC, Korn T, Nielsen P, Weller H, Schramm C, Lüth S, Lohse AW, Heeren J, Herkel J. Carambia A, et al. Among authors: heeren j. J Hepatol. 2015 Jun;62(6):1349-56. doi: 10.1016/j.jhep.2015.01.006. Epub 2015 Jan 21. J Hepatol. 2015. PMID: 25617499 Free article.
235 results