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ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo.
Samuelsen Ø, Åstrand OAH, Fröhlich C, Heikal A, Skagseth S, Carlsen TJO, Leiros HS, Bayer A, Schnaars C, Kildahl-Andersen G, Lauksund S, Finke S, Huber S, Gjøen T, Andresen AMS, Økstad OA, Rongved P. Samuelsen Ø, et al. Among authors: heikal a. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19. doi: 10.1128/AAC.02415-19. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32179522 Free PMC article.
Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors.
Schnaars C, Kildahl-Andersen G, Prandina A, Popal R, Radix S, Le Borgne M, Gjøen T, Andresen AMS, Heikal A, Økstad OA, Fröhlich C, Samuelsen Ø, Lauksund S, Jordheim LP, Rongved P, Åstrand OAH. Schnaars C, et al. Among authors: heikal a. ACS Infect Dis. 2018 Sep 14;4(9):1407-1422. doi: 10.1021/acsinfecdis.8b00137. Epub 2018 Aug 2. ACS Infect Dis. 2018. PMID: 30022668
Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2.
Harbison-Price N, Ferguson SA, Heikal A, Taiaroa G, Hards K, Nakatani Y, Rennison D, Brimble MA, El-Deeb IM, Bohlmann L, McDevitt CA, von Itzstein M, Walker MJ, Cook GM. Harbison-Price N, et al. Among authors: heikal a. mSphere. 2020 Mar 18;5(2):e00157-20. doi: 10.1128/mSphere.00157-20. mSphere. 2020. PMID: 32188750 Free PMC article.
Bridging the gap between a TB drug and its target.
Cook GM, Heikal A. Cook GM, et al. Among authors: heikal a. Sci Transl Med. 2012 Sep 5;4(150):150fs33. doi: 10.1126/scitranslmed.3004816. Sci Transl Med. 2012. PMID: 22956196
72 results