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Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis.
Zhang Y, Cedervall J, Hamidi A, Herre M, Viitaniemi K, D'Amico G, Miao Z, Unnithan RVM, Vaccaro A, van Hooren L, Georganaki M, Thulin Å, Qiao Q, Andrae J, Siegbahn A, Heldin CH, Alitalo K, Betsholtz C, Dimberg A, Olsson AK. Zhang Y, et al. Among authors: heldin ch. Cancer Res. 2020 Aug 15;80(16):3345-3358. doi: 10.1158/0008-5472.CAN-19-3533. Epub 2020 Jun 25. Cancer Res. 2020. PMID: 32586981
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin CH, Ostman A, Ylä-Herttuala S. Leppänen O, et al. Among authors: heldin ch. Circulation. 2004 Mar 9;109(9):1140-6. doi: 10.1161/01.CIR.0000117234.08626.7C. Epub 2004 Feb 9. Circulation. 2004. PMID: 14769706
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
Furuhashi M, Sjöblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin CH, Ostman A. Furuhashi M, et al. Among authors: heldin ch. Cancer Res. 2004 Apr 15;64(8):2725-33. doi: 10.1158/0008-5472.can-03-1489. Cancer Res. 2004. PMID: 15087386
PDGF receptors as targets in tumor treatment.
Ostman A, Heldin CH. Ostman A, et al. Among authors: heldin ch. Adv Cancer Res. 2007;97:247-74. doi: 10.1016/S0065-230X(06)97011-0. Adv Cancer Res. 2007. PMID: 17419949 Review.
Autocrine PDGF stimulation in malignancies.
Heldin CH. Heldin CH. Ups J Med Sci. 2012 May;117(2):83-91. doi: 10.3109/03009734.2012.658119. Ups J Med Sci. 2012. PMID: 22512244 Free PMC article. Review.
581 results