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Page 1
Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
Beetham H, Griffith BGC, Murina O, Loftus AEP, Parry DA, Temps C, Culley J, Muir M, Unciti-Broceta A, Sims AH, Byron A, Brunton VG. Beetham H, et al. Cancer Res. 2022 Feb 15;82(4):632-647. doi: 10.1158/0008-5472.CAN-21-0373. Cancer Res. 2022. PMID: 34921014 Free PMC article.
A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Temps C, Lietha D, Webb ER, Li XF, Dawson JC, Muir M, Macleod KG, Valero T, Munro AF, Contreras-Montoya R, Luque-Ortega JR, Fraser C, Beetham H, Schoenherr C, Lopalco M, Arends MJ, Frame MC, Qian BZ, Brunton VG, Carragher NO, Unciti-Broceta A. Temps C, et al. Among authors: beetham h. Cancer Res. 2021 Nov 1;81(21):5438-5450. doi: 10.1158/0008-5472.CAN-21-0613. Epub 2021 Aug 20. Cancer Res. 2021. PMID: 34417202 Free PMC article.
A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells.
Hall J, Daniszewski M, Cheung S, Shobhana K, Kumar H, Liang HH, Beetham H, Cho E, Abbott C, Hewitt AW, Simpson KJ, Guymer RH, Paull D, Pébay A, Lidgerwood GE. Hall J, et al. Among authors: beetham h. SLAS Technol. 2023 Aug 30:S2472-6303(23)00055-9. doi: 10.1016/j.slast.2023.08.006. Online ahead of print. SLAS Technol. 2023. PMID: 37657710 Free article.
E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.
Godwin TD, Kelly ST, Brew TP, Bougen-Zhukov NM, Single AB, Chen A, Stylianou CE, Harris LD, Currie SK, Telford BJ, Beetham HG, Evans GB, Black MA, Guilford PJ. Godwin TD, et al. Among authors: beetham hg. Gastric Cancer. 2019 Mar;22(2):273-286. doi: 10.1007/s10120-018-0859-1. Epub 2018 Jul 31. Gastric Cancer. 2019. PMID: 30066183 Free PMC article.