Hettne KM - Search Results

1

Literature-aided interpretation of gene expression data with the weighted global test.

Jelier R, Goeman JJ, Hettne KM, Schuemie MJ, den Dunnen JT, 't Hoen PA. Jelier R, et al. Among authors: hettne km. Brief Bioinform. 2011 Sep;12(5):518-29. doi: 10.1093/bib/bbq082. Epub 2010 Dec 22. Brief Bioinform. 2011. PMID: 21183478 Review.

2

Simultaneous Enrichment Analysis of all Possible Gene-sets: Unifying Self-Contained and Competitive Methods.

Ebrahimpoor M, Spitali P, Hettne K, Tsonaka R, Goeman J. Ebrahimpoor M, et al. Brief Bioinform. 2020 Jul 15;21(4):1302-1312. doi: 10.1093/bib/bbz074. Brief Bioinform. 2020. PMID: 31297505 Free PMC article. Review.

3

Common disease signatures from gene expression analysis in Huntington's disease human blood and brain.

Mina E, van Roon-Mom W, Hettne K, van Zwet E, Goeman J, Neri C, A C 't Hoen P, Mons B, Roos M. Mina E, et al. Orphanet J Rare Dis. 2016 Aug 1;11(1):97. doi: 10.1186/s13023-016-0475-2. Orphanet J Rare Dis. 2016. PMID: 27476530 Free PMC article.

4

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data.

Hettne KM, Boorsma A, van Dartel DA, Goeman JJ, de Jong E, Piersma AH, Stierum RH, Kleinjans JC, Kors JA. Hettne KM, et al. BMC Med Genomics. 2013 Jan 29;6:2. doi: 10.1186/1755-8794-6-2. BMC Med Genomics. 2013. PMID: 23356878 Free PMC article.

5

The Implicitome: A Resource for Rationalizing Gene-Disease Associations.

Hettne KM, Thompson M, van Haagen HH, van der Horst E, Kaliyaperumal R, Mina E, Tatum Z, Laros JF, van Mulligen EM, Schuemie M, Aten E, Li TS, Bruskiewich R, Good BM, Su AI, Kors JA, den Dunnen J, van Ommen GJ, Roos M, 't Hoen PA, Mons B, Schultes EA. Hettne KM, et al. PLoS One. 2016 Feb 26;11(2):e0149621. doi: 10.1371/journal.pone.0149621. eCollection 2016. PLoS One. 2016. PMID: 26919047 Free PMC article.

6

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.

Toonen LJA, Overzier M, Evers MM, Leon LG, van der Zeeuw SAJ, Mei H, Kielbasa SM, Goeman JJ, Hettne KM, Magnusson OT, Poirel M, Seyer A, 't Hoen PAC, van Roon-Mom WMC. Toonen LJA, et al. Among authors: hettne km. Mol Neurodegener. 2018 Jun 22;13(1):31. doi: 10.1186/s13024-018-0261-9. Mol Neurodegener. 2018. PMID: 29929540 Free PMC article.

7

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.

Malas TB, Leonhard WN, Bange H, Granchi Z, Hettne KM, Van Westen GJP, Price LS, 't Hoen PAC, Peters DJM. Malas TB, et al. Among authors: hettne km. EBioMedicine. 2020 Jan;51:102585. doi: 10.1016/j.ebiom.2019.11.046. Epub 2019 Dec 24. EBioMedicine. 2020. PMID: 31879244 Free PMC article.

8

Drug prioritization using the semantic properties of a knowledge graph.

Malas TB, Vlietstra WJ, Kudrin R, Starikov S, Charrout M, Roos M, Peters DJM, Kors JA, Vos R, 't Hoen PAC, van Mulligen EM, Hettne KM. Malas TB, et al. Among authors: hettne km. Sci Rep. 2019 Apr 18;9(1):6281. doi: 10.1038/s41598-019-42806-6. Sci Rep. 2019. PMID: 31000794 Free PMC article.

9

A dictionary to identify small molecules and drugs in free text.

Hettne KM, Stierum RH, Schuemie MJ, Hendriksen PJ, Schijvenaars BJ, Mulligen EM, Kleinjans J, Kors JA. Hettne KM, et al. Bioinformatics. 2009 Nov 15;25(22):2983-91. doi: 10.1093/bioinformatics/btp535. Epub 2009 Sep 16. Bioinformatics. 2009. PMID: 19759196

10

Rewriting and suppressing UMLS terms for improved biomedical term identification.

Hettne KM, van Mulligen EM, Schuemie MJ, Schijvenaars BJ, Kors JA. Hettne KM, et al. J Biomed Semantics. 2010 Mar 31;1(1):5. doi: 10.1186/2041-1480-1-5. J Biomed Semantics. 2010. PMID: 20618981 Free PMC article.

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