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RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia.
Pham LT, Peng H, Ueno M, Kohno S, Kasada A, Hosomichi K, Sato T, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Xiao B, Worley PF, Takahashi C, Tajima A, Hirao A. Pham LT, et al. Among authors: hirao a. Biochem Biophys Res Commun. 2022 Sep 17;621:74-79. doi: 10.1016/j.bbrc.2022.06.089. Epub 2022 Jun 30. Biochem Biophys Res Commun. 2022. PMID: 35810594
NKX2.2 suppresses self-renewal of glioma-initiating cells.
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A. Muraguchi T, et al. Among authors: hirao a. Cancer Res. 2011 Feb 1;71(3):1135-45. doi: 10.1158/0008-5472.CAN-10-2304. Epub 2010 Dec 17. Cancer Res. 2011. PMID: 21169405
mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Hoshii T, Tadokoro Y, Naka K, Ooshio T, Muraguchi T, Sugiyama N, Soga T, Araki K, Yamamura K, Hirao A. Hoshii T, et al. Among authors: hirao a. J Clin Invest. 2012 Jun;122(6):2114-29. doi: 10.1172/JCI62279. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622041 Free PMC article.
Nucleostemin in injury-induced liver regeneration.
Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A. Shugo H, et al. Among authors: hirao a. Stem Cells Dev. 2012 Nov 1;21(16):3044-54. doi: 10.1089/scd.2011.0725. Epub 2012 Jul 9. Stem Cells Dev. 2012. PMID: 22775537
Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.
Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A. Hoshii T, et al. Among authors: hirao a. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3805-10. doi: 10.1073/pnas.1320265111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567410 Free PMC article.
278 results