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Small-Molecule Inhibition of the UNC119-Cargo Interaction.
Mejuch T, Garivet G, Hofer W, Kaiser N, Fansa EK, Ehrt C, Koch O, Baumann M, Ziegler S, Wittinghofer A, Waldmann H. Mejuch T, et al. Among authors: hofer w. Angew Chem Int Ed Engl. 2017 May 22;56(22):6181-6186. doi: 10.1002/anie.201701905. Epub 2017 May 4. Angew Chem Int Ed Engl. 2017. PMID: 28471079
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.
Cromm PM, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN. Cromm PM, et al. Among authors: hofer w. Chembiochem. 2019 Dec 13;20(24):2987-2990. doi: 10.1002/cbic.201900615. Epub 2019 Nov 19. Chembiochem. 2019. PMID: 31680402 Free PMC article.
The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis.
Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW, Waldmann H. Laraia L, et al. Among authors: hofer w. Nat Chem Biol. 2019 Jul;15(7):710-720. doi: 10.1038/s41589-019-0307-5. Epub 2019 Jun 20. Nat Chem Biol. 2019. PMID: 31222192
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives.
Hofer W, Oueis E, Fayad AA, Deschner F, Andreas A, de Carvalho LP, Hüttel S, Bernecker S, Pätzold L, Morgenstern B, Zaburannyi N, Bischoff M, Stadler M, Held J, Herrmann J, Müller R. Hofer W, et al. Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202202816. doi: 10.1002/anie.202202816. Epub 2022 Jun 13. Angew Chem Int Ed Engl. 2022. PMID: 35485800 Free PMC article.
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application.
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany AM, Große M, Stadler M, Bischoff M, Hirsch AKH, Held J, Herrmann J, Müller R. Hofer W, et al. Angew Chem Int Ed Engl. 2024 May 6;63(19):e202319765. doi: 10.1002/anie.202319765. Epub 2024 Apr 3. Angew Chem Int Ed Engl. 2024. PMID: 38502093
The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection.
Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker TR, Neumann-Schaal M, Paul LS, Nübel U, Bartel J, Kany AM, Zühlke D, Bernecker S, Jansen R, Sievers S, Riedel K, Herrmann J, Müller R, Fuchs TM, Strowig T. Bublitz A, et al. Among authors: hofer w. Cell Host Microbe. 2023 May 10;31(5):734-750.e8. doi: 10.1016/j.chom.2023.04.003. Epub 2023 Apr 24. Cell Host Microbe. 2023. PMID: 37098342 Free article.
134 results