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Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β.
J Biol Chem. 2020 Feb 7;295(6):1613-1622. doi: 10.1074/jbc.RA119.011569. Epub 2019 Dec 31.
J Biol Chem. 2020.
PMID: 31892517
Free PMC article.
Structure and function relationships in mammalian DNA polymerases.
Hoitsma NM, Whitaker AM, Schaich MA, Smith MR, Fairlamb MS, Freudenthal BD.
Hoitsma NM, et al.
Cell Mol Life Sci. 2020 Jan;77(1):35-59. doi: 10.1007/s00018-019-03368-y. Epub 2019 Nov 13.
Cell Mol Life Sci. 2020.
PMID: 31722068
Free PMC article.
Review.
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AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.
Hoitsma NM, Whitaker AM, Beckwitt EC, Jang S, Agarwal PK, Van Houten B, Freudenthal BD.
Hoitsma NM, et al.
Nucleic Acids Res. 2020 Jul 27;48(13):7345-7355. doi: 10.1093/nar/gkaa496.
Nucleic Acids Res. 2020.
PMID: 32542366
Free PMC article.
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Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker.
Hoitsma NM, Click TH, Agarwal PK, Freudenthal BD.
Hoitsma NM, et al.
Comput Struct Biotechnol J. 2021 May 25;19:3293-3302. doi: 10.1016/j.csbj.2021.05.035. eCollection 2021.
Comput Struct Biotechnol J. 2021.
PMID: 34188778
Free PMC article.
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Structural basis for APE1 processing DNA damage in the nucleosome.
Weaver TM, Hoitsma NM, Spencer JJ, Gakhar L, Schnicker NJ, Freudenthal BD.
Weaver TM, et al. Among authors: hoitsma nm.
Nat Commun. 2022 Sep 14;13(1):5390. doi: 10.1038/s41467-022-33057-7.
Nat Commun. 2022.
PMID: 36104361
Free PMC article.
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Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics.
Hoitsma NM, Norris J, Khoang TH, Kaushik V, Chadda R, Antony E, Hedglin M, Freudenthal BD.
Hoitsma NM, et al.
Nucleic Acids Res. 2023 Jul 21;51(13):6738-6753. doi: 10.1093/nar/gkad481.
Nucleic Acids Res. 2023.
PMID: 37264933
Free PMC article.
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