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Poised RNA polymerase II gives pause for thought.
Margaritis T, Holstege FC. Margaritis T, et al. Cell. 2008 May 16;133(4):581-4. doi: 10.1016/j.cell.2008.04.027. Cell. 2008. PMID: 18485867 Free article. Review.
Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.
Kemmeren P, Sameith K, van de Pasch LA, Benschop JJ, Lenstra TL, Margaritis T, O'Duibhir E, Apweiler E, van Wageningen S, Ko CW, van Heesch S, Kashani MM, Ampatziadis-Michailidis G, Brok MO, Brabers NA, Miles AJ, Bouwmeester D, van Hooff SR, van Bakel H, Sluiters E, Bakker LV, Snel B, Lijnzaad P, van Leenen D, Groot Koerkamp MJ, Holstege FC. Kemmeren P, et al. Cell. 2014 Apr 24;157(3):740-52. doi: 10.1016/j.cell.2014.02.054. Cell. 2014. PMID: 24766815 Free article.
Cell cycle population effects in perturbation studies.
O'Duibhir E, Lijnzaad P, Benschop JJ, Lenstra TL, van Leenen D, Groot Koerkamp MJ, Margaritis T, Brok MO, Kemmeren P, Holstege FC. O'Duibhir E, et al. Mol Syst Biol. 2014 Jun 21;10(6):732. doi: 10.15252/msb.20145172. Mol Syst Biol. 2014. PMID: 24952590 Free PMC article.
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.
Gómez-Herreros F, Margaritis T, Rodríguez-Galán O, Pelechano V, Begley V, Millán-Zambrano G, Morillo-Huesca M, Muñoz-Centeno MC, Pérez-Ortín JE, de la Cruz J, Holstege FCP, Chávez S. Gómez-Herreros F, et al. Among authors: holstege fcp. Nucleic Acids Res. 2017 Sep 19;45(16):9302-9318. doi: 10.1093/nar/gkx529. Nucleic Acids Res. 2017. PMID: 28637236 Free PMC article.
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, Cuppen E, Hendrickx APA, van den Heuvel-Eibrink MM, Heitzer E, Lanz H, Beekman J, Murk JL, Masereeuw R, Holstege F, Drost J, Verhaar MC, Clevers H. Schutgens F, et al. Nat Biotechnol. 2019 Mar;37(3):303-313. doi: 10.1038/s41587-019-0048-8. Epub 2019 Mar 4. Nat Biotechnol. 2019. PMID: 30833775
174 results