Honegger A - Search Results

1

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.

Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A. Deluigi M, et al. Among authors: honegger a. Sci Adv. 2021 Jan 27;7(5):eabe5504. doi: 10.1126/sciadv.abe5504. Print 2021 Jan. Sci Adv. 2021. PMID: 33571132 Free PMC article.

2

Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.

Wu Y, Honegger A, Batyuk A, Mittl PRE, Plückthun A. Wu Y, et al. Among authors: honegger a. J Mol Biol. 2018 Jul 6;430(14):2128-2138. doi: 10.1016/j.jmb.2017.10.032. Epub 2017 Nov 8. J Mol Biol. 2018. PMID: 29126898

3

Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.

Ernst P, Honegger A, van der Valk F, Ewald C, Mittl PRE, Plückthun A. Ernst P, et al. Among authors: honegger a. Sci Rep. 2019 Nov 7;9(1):16162. doi: 10.1038/s41598-019-52121-9. Sci Rep. 2019. PMID: 31700118 Free PMC article.

4

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.

Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A. Dreier B, et al. Among authors: honegger a. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E869-77. doi: 10.1073/pnas.1213653110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431166 Free PMC article.

5

Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.

Reichen C, Hansen S, Forzani C, Honegger A, Fleishman SJ, Zhou T, Parmeggiani F, Ernst P, Madhurantakam C, Ewald C, Mittl PRE, Zerbe O, Baker D, Caflisch A, Plückthun A. Reichen C, et al. Among authors: honegger a. J Mol Biol. 2016 Nov 6;428(22):4467-4489. doi: 10.1016/j.jmb.2016.09.012. Epub 2016 Sep 21. J Mol Biol. 2016. PMID: 27664438

6

Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions.

Jost C, Stüber JC, Honegger A, Wu Y, Batyuk A, Plückthun A. Jost C, et al. Among authors: honegger a. Protein Sci. 2017 Sep;26(9):1796-1806. doi: 10.1002/pro.3216. Epub 2017 Jul 5. Protein Sci. 2017. PMID: 28639341 Free PMC article.

7

Rigidly connected multispecific artificial binders with adjustable geometries.

Wu Y, Batyuk A, Honegger A, Brandl F, Mittl PRE, Plückthun A. Wu Y, et al. Among authors: honegger a. Sci Rep. 2017 Sep 11;7(1):11217. doi: 10.1038/s41598-017-11472-x. Sci Rep. 2017. PMID: 28894181 Free PMC article.

8

Yet another numbering scheme for immunoglobulin variable domains: an automatic modeling and analysis tool.

Honegger A, Plückthun A. Honegger A, et al. J Mol Biol. 2001 Jun 8;309(3):657-70. doi: 10.1006/jmbi.2001.4662. J Mol Biol. 2001. PMID: 11397087

9

The influence of the buried glutamine or glutamate residue in position 6 on the structure of immunoglobulin variable domains.

Honegger A, Plückthun A. Honegger A, et al. J Mol Biol. 2001 Jun 8;309(3):687-99. doi: 10.1006/jmbi.2001.4664. J Mol Biol. 2001. PMID: 11397089

10

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability.

Röthlisberger D, Honegger A, Plückthun A. Röthlisberger D, et al. Among authors: honegger a. J Mol Biol. 2005 Apr 8;347(4):773-89. doi: 10.1016/j.jmb.2005.01.053. J Mol Biol. 2005. PMID: 15769469

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