Horsman GP - Search Results

1

Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway.

Horsman GP, Ke J, Dai S, Seah SY, Bolin JT, Eltis LD. Horsman GP, et al. Biochemistry. 2006 Sep 19;45(37):11071-86. doi: 10.1021/bi0611098. Biochemistry. 2006. PMID: 16964968 Free PMC article.

2

A glutathione S-transferase catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls.

Fortin PD, Horsman GP, Yang HM, Eltis LD. Fortin PD, et al. Among authors: horsman gp. J Bacteriol. 2006 Jun;188(12):4424-30. doi: 10.1128/JB.01849-05. J Bacteriol. 2006. PMID: 16740949 Free PMC article.

3

Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites.

Seah SY, Ke J, Denis G, Horsman GP, Fortin PD, Whiting CJ, Eltis LD. Seah SY, et al. Among authors: horsman gp. J Bacteriol. 2007 Jun;189(11):4038-45. doi: 10.1128/JB.01950-06. Epub 2007 Apr 6. J Bacteriol. 2007. PMID: 17416660 Free PMC article.

4

The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad.

Horsman GP, Bhowmik S, Seah SY, Kumar P, Bolin JT, Eltis LD. Horsman GP, et al. J Biol Chem. 2007 Jul 6;282(27):19894-904. doi: 10.1074/jbc.M702237200. Epub 2007 Apr 18. J Biol Chem. 2007. PMID: 17442675 Free article.

5

The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization.

Bhowmik S, Horsman GP, Bolin JT, Eltis LD. Bhowmik S, et al. Among authors: horsman gp. J Biol Chem. 2007 Dec 14;282(50):36377-85. doi: 10.1074/jbc.M707035200. Epub 2007 Oct 11. J Biol Chem. 2007. PMID: 17932031 Free article.

6

Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad.

Ruzzini AC, Ghosh S, Horsman GP, Foster LJ, Bolin JT, Eltis LD. Ruzzini AC, et al. Among authors: horsman gp. J Am Chem Soc. 2012 Mar 14;134(10):4615-24. doi: 10.1021/ja208544g. Epub 2012 Mar 5. J Am Chem Soc. 2012. PMID: 22339283

7

The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage.

Ruzzini AC, Horsman GP, Eltis LD. Ruzzini AC, et al. Among authors: horsman gp. Biochemistry. 2012 Jul 24;51(29):5831-40. doi: 10.1021/bi300663r. Epub 2012 Jul 11. Biochemistry. 2012. PMID: 22747426

8

Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.

Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD. Lack NA, et al. Among authors: horsman gp. J Biol Chem. 2010 Jan 1;285(1):434-43. doi: 10.1074/jbc.M109.058081. Epub 2009 Oct 29. J Biol Chem. 2010. PMID: 19875455 Free PMC article.

9

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase.

Horsman GP, Jirasek A, Vaillancourt FH, Barbosa CJ, Jarzecki AA, Xu C, Mekmouche Y, Spiro TG, Lipscomb JD, Blades MW, Turner RF, Eltis LD. Horsman GP, et al. J Am Chem Soc. 2005 Dec 7;127(48):16882-91. doi: 10.1021/ja053800o. J Am Chem Soc. 2005. PMID: 16316234 Free PMC article.

10

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates.

Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B. Guo X, et al. Among authors: horsman gp. Biochemistry. 2018 Feb 13;57(6):1003-1011. doi: 10.1021/acs.biochem.7b01219. Epub 2018 Jan 30. Biochemistry. 2018. PMID: 29341603

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