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The gut microbiota as a modulator of innate immunity during melioidosis.
Lankelma JM, Birnie E, Weehuizen TAF, Scicluna BP, Belzer C, Houtkooper RH, Roelofs JJTH, de Vos AF, van der Poll T, Budding AE, Wiersinga WJ. Lankelma JM, et al. Among authors: houtkooper rh. PLoS Negl Trop Dis. 2017 Apr 19;11(4):e0005548. doi: 10.1371/journal.pntd.0005548. eCollection 2017 Apr. PLoS Negl Trop Dis. 2017. PMID: 28422970 Free PMC article.
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin.
Ramirez-Moral I, Yu X, Butler JM, van Weeghel M, Otto NA, Ferreira BL, Maele LV, Sirard JC, de Vos AF, de Jong MD, Houtkooper RH, van der Poll T. Ramirez-Moral I, et al. Among authors: houtkooper rh. Mucosal Immunol. 2021 May;14(3):594-604. doi: 10.1038/s41385-021-00377-8. Epub 2021 Feb 4. Mucosal Immunol. 2021. PMID: 33542495 Free article.
Human alveolar macrophages do not rely on glucose metabolism upon activation by lipopolysaccharide.
Pereverzeva L, van Linge CCA, Schuurman AR, Klarenbeek AM, Ramirez Moral I, Otto NA, Peters-Sengers H, Butler JM, Schomakers BV, van Weeghel M, Houtkooper RH, Wiersinga WJ, Bonta PI, Annema JT, de Vos AF, van der Poll T. Pereverzeva L, et al. Among authors: houtkooper rh. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 1;1868(10):166488. doi: 10.1016/j.bbadis.2022.166488. Epub 2022 Jul 11. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35835414 Free article.
Intracellular pyruvate levels positively correlate with cytokine production capacity in tolerant monocytes from patients with pneumonia.
Otto NA, Butler JM, Schuurman AR, Brands X, Haak BW, Klarenbeek AM, van Weeghel M, Houtkooper RH, Jakobs ME, Faber DR, de Vos AF, Wiersinga WJ, Scicluna BP, van der Poll T. Otto NA, et al. Among authors: houtkooper rh. Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166519. doi: 10.1016/j.bbadis.2022.166519. Epub 2022 Aug 12. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35964875 Free article.
Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia.
Schuurman AR, Butler JM, Michels EHA, Otto NA, Brands X, Haak BW, Uhel F, Klarenbeek AM, Faber DR, Schomakers BV, van Weeghel M, de Vos AF, Scicluna BP, Houtkooper RH, Wiersinga WJ, van der Poll T. Schuurman AR, et al. Among authors: houtkooper rh. iScience. 2023 Jun 19;26(7):107181. doi: 10.1016/j.isci.2023.107181. eCollection 2023 Jul 21. iScience. 2023. PMID: 37496676 Free PMC article.
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
Guo L, Appelman B, Mooij-Kalverda K, Houtkooper RH, van Weeghel M, Vaz FM, Dijkhuis A, Dekker T, Smids BS, Duitman JW, Bugiani M, Brinkman P, Sikkens JJ, Lavell HAA, Wüst RCI, van Vugt M, Lutter R; Amsterdam UMC COVID-19 Biobank study Group. Guo L, et al. Among authors: houtkooper rh. EBioMedicine. 2023 Aug;94:104729. doi: 10.1016/j.ebiom.2023.104729. Epub 2023 Jul 26. EBioMedicine. 2023. PMID: 37506544 Free PMC article.
184 results