Hu X - Search Results

1

A novel PEGylated interferon beta-1a for multiple sclerosis: safety, pharmacology, and biology.

Hu X, Miller L, Richman S, Hitchman S, Glick G, Liu S, Zhu Y, Crossman M, Nestorov I, Gronke RS, Baker DP, Rogge M, Subramanyam M, Davar G. Hu X, et al. J Clin Pharmacol. 2012 Jun;52(6):798-808. doi: 10.1177/0091270011407068. Epub 2011 Jun 16. J Clin Pharmacol. 2012. PMID: 21680782 Clinical Trial.

2

PEGylated interferon beta-1a: meeting an unmet medical need in the treatment of relapsing multiple sclerosis.

Baker DP, Pepinsky RB, Brickelmaier M, Gronke RS, Hu X, Olivier K, Lerner M, Miller L, Crossman M, Nestorov I, Subramanyam M, Hitchman S, Glick G, Richman S, Liu S, Zhu Y, Panzara MA, Davar G. Baker DP, et al. Among authors: hu x. J Interferon Cytokine Res. 2010 Oct;30(10):777-85. doi: 10.1089/jir.2010.0092. J Interferon Cytokine Res. 2010. PMID: 20836711 Review.

3

In vivo pharmacology and toxicology evaluation of polyethylene glycol-conjugated interferon beta-1a.

Hu X, Olivier K, Polack E, Crossman M, Zokowski K, Gronke RS, Parker S, Li Z, Nestorov I, Baker DP, Clarke J, Subramanyam M. Hu X, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):984-96. doi: 10.1124/jpet.111.180661. Epub 2011 Jun 20. J Pharmacol Exp Ther. 2011. PMID: 21690216

4

Pharmacokinetics, pharmacodynamics, and safety of peginterferon beta-1a in subjects with normal or impaired renal function.

Hu X, Seddighzadeh A, Stecher S, Zhu Y, Goyal J, Matson M, Marbury T, Smith W, Nestorov I, Hung S. Hu X, et al. J Clin Pharmacol. 2015 Feb;55(2):179-88. doi: 10.1002/jcph.390. Epub 2014 Sep 23. J Clin Pharmacol. 2015. PMID: 25187030 Free PMC article. Clinical Trial.

5

Pharmacokinetics and pharmacodynamics of peginterferon beta-1a in patients with relapsing-remitting multiple sclerosis in the randomized ADVANCE study.

Hu X, Cui Y, White J, Zhu Y, Deykin A, Nestorov I, Hung S. Hu X, et al. Br J Clin Pharmacol. 2015 Mar;79(3):514-22. doi: 10.1111/bcp.12521. Br J Clin Pharmacol. 2015. PMID: 25265472 Free PMC article. Clinical Trial.

6

COMPARE: Pharmacokinetic profiles of subcutaneous peginterferon beta-1a and subcutaneous interferon beta-1a over 2 weeks in healthy subjects.

Hu X, Shang S, Nestorov I, Hasan J, Seddighzadeh A, Dawson K, Sperling B, Werneburg B. Hu X, et al. Br J Clin Pharmacol. 2016 Aug;82(2):380-8. doi: 10.1111/bcp.12968. Epub 2016 May 29. Br J Clin Pharmacol. 2016. PMID: 27060836 Free PMC article. Clinical Trial.

7

Population-Based Pharmacokinetic and Exposure-Efficacy Analyses of Peginterferon Beta-1a in Patients With Relapsing Multiple Sclerosis.

Hu X, Hang Y, Cui Y, Zhang J, Liu S, Seddighzadeh A, Deykin A, Nestorov I. Hu X, et al. J Clin Pharmacol. 2017 Aug;57(8):1005-1016. doi: 10.1002/jcph.883. Epub 2017 Apr 10. J Clin Pharmacol. 2017. PMID: 28394418 Free PMC article. Clinical Trial.

8

Analysis of peginterferon β-1a exposure and Gd-enhanced lesion or T2 lesion response in relapsing-remitting multiple sclerosis patients.

Hang Y, Hu X, Zhang J, Liu S, Deykin A, Nestorov I. Hang Y, et al. Among authors: hu x. J Pharmacokinet Pharmacodyn. 2016 Aug;43(4):371-83. doi: 10.1007/s10928-016-9477-x. Epub 2016 Jun 14. J Pharmacokinet Pharmacodyn. 2016. PMID: 27299457 Free PMC article. Clinical Trial.

9

Peginterferon Beta-1a Shows Antitumor Activity as a Single Agent and Enhances Efficacy of Standard of Care Cancer Therapeutics in Human Melanoma, Breast, Renal, and Colon Xenograft Models.

Boccia A, Virata C, Lindner D, English N, Pathan N, Brickelmaier M, Hu X, Gardner JL, Peng L, Wang X, Zhang X, Yang L, Perron K, Yco G, Kelly R, Gamez J, Scripps T, Bennett D, Joseph IB, Baker DP. Boccia A, et al. Among authors: hu x. J Interferon Cytokine Res. 2017 Jan;37(1):20-31. doi: 10.1089/jir.2016.0027. Epub 2016 Nov 11. J Interferon Cytokine Res. 2017. PMID: 27835061

10

Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer's disease in 3xTg-AD mice.

Hu XH, Yu KY, Li XX, Zhang JN, Jiao JJ, Wang ZJ, Cai HY, Wang L, He YX, Wu MN. Hu XH, et al. J Gerontol A Biol Sci Med Sci. 2024 Apr 29:glae115. doi: 10.1093/gerona/glae115. Online ahead of print. J Gerontol A Biol Sci Med Sci. 2024. PMID: 38682858

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