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DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.
Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL; WHI-EMPC Investigators; Fiorito G; CHARGE epigenetics of Coronary Heart Disease; Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A. Ligthart S, et al. Among authors: huan t. Genome Biol. 2016 Dec 12;17(1):255. doi: 10.1186/s13059-016-1119-5. Genome Biol. 2016. PMID: 27955697 Free PMC article.
A systems biology framework identifies molecular underpinnings of coronary heart disease.
Huan T, Zhang B, Wang Z, Joehanes R, Zhu J, Johnson AD, Ying S, Munson PJ, Raghavachari N, Wang R, Liu P, Courchesne P, Hwang SJ, Assimes TL, McPherson R, Samani NJ, Schunkert H; Coronary ARteryDIsease Genome wide Replication and Meta-analysis (CARDIoGRAM) Consortium, International Consortium for Blood Pressure GWAS (ICBP); Meng Q, Suver C, O'Donnell CJ, Derry J, Yang X, Levy D. Huan T, et al. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1427-34. doi: 10.1161/ATVBAHA.112.300112. Epub 2013 Mar 28. Arterioscler Thromb Vasc Biol. 2013. PMID: 23539213 Free PMC article.
Gene expression signatures of coronary heart disease.
Joehanes R, Ying S, Huan T, Johnson AD, Raghavachari N, Wang R, Liu P, Woodhouse KA, Sen SK, Tanriverdi K, Courchesne P, Freedman JE, O'Donnell CJ, Levy D, Munson PJ. Joehanes R, et al. Among authors: huan t. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1418-26. doi: 10.1161/ATVBAHA.112.301169. Epub 2013 Mar 28. Arterioscler Thromb Vasc Biol. 2013. PMID: 23539218 Free PMC article.
Sex- and age-interacting eQTLs in human complex diseases.
Yao C, Joehanes R, Johnson AD, Huan T, Esko T, Ying S, Freedman JE, Murabito J, Lunetta KL, Metspalu A, Munson PJ, Levy D. Yao C, et al. Among authors: huan t. Hum Mol Genet. 2014 Apr 1;23(7):1947-56. doi: 10.1093/hmg/ddt582. Epub 2013 Nov 15. Hum Mol Genet. 2014. PMID: 24242183 Free PMC article.
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.
Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Reilly MP; Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium; Lusis AJ, Samani NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL. Mäkinen VP, et al. Among authors: huan t. PLoS Genet. 2014 Jul 17;10(7):e1004502. doi: 10.1371/journal.pgen.1004502. eCollection 2014 Jul. PLoS Genet. 2014. PMID: 25033284 Free PMC article.
Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.
Yao C, Chen BH, Joehanes R, Otlu B, Zhang X, Liu C, Huan T, Tastan O, Cupples LA, Meigs JB, Fox CS, Freedman JE, Courchesne P, O'Donnell CJ, Munson PJ, Keles S, Levy D. Yao C, et al. Among authors: huan t. Circulation. 2015 Feb 10;131(6):536-49. doi: 10.1161/CIRCULATIONAHA.114.010696. Epub 2014 Dec 22. Circulation. 2015. PMID: 25533967 Free PMC article.
Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.
Huan T, Rong J, Tanriverdi K, Meng Q, Bhattacharya A, McManus DD, Joehanes R, Assimes TL, McPherson R, Samani NJ, Erdmann J, Schunkert H, Courchesne P, Munson PJ, Johnson AD, O'Donnell CJ, Zhang B, Larson MG, Freedman JE, Levy D, Yang X. Huan T, et al. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):1011-21. doi: 10.1161/ATVBAHA.114.305176. Epub 2015 Feb 5. Arterioscler Thromb Vasc Biol. 2015. PMID: 25657313 Free PMC article.
A meta-analysis of gene expression signatures of blood pressure and hypertension.
Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, Yao C, Ying SX, Courchesne P, Milani L, Raghavachari N, Wang R, Liu P, Reinmaa E, Dehghan A, Hofman A, Uitterlinden AG, Hernandez DG, Bandinelli S, Singleton A, Melzer D, Metspalu A, Carstensen M, Grallert H, Herder C, Meitinger T, Peters A, Roden M, Waldenberger M, Dörr M, Felix SB, Zeller T; International Consortium for Blood Pressure GWAS (ICBP); Vasan R, O'Donnell CJ, Munson PJ, Yang X, Prokisch H, Völker U, van Meurs JB, Ferrucci L, Levy D. Huan T, et al. PLoS Genet. 2015 Mar 18;11(3):e1005035. doi: 10.1371/journal.pgen.1005035. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25785607 Free PMC article.
245 results