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Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties.
Lee YS, Chuang SH, Huang LY, Lai CL, Lin YH, Yang JY, Liu CW, Yang SC, Lin HS, Chang CC, Lai JY, Jian PS, Lam K, Chang JM, Lau JY, Huang JJ. Lee YS, et al. Among authors: huang jj, huang ly. J Med Chem. 2014 May 22;57(10):4098-110. doi: 10.1021/jm401990s. Epub 2014 May 7. J Med Chem. 2014. PMID: 24773549
Inhibition of Hec1 as a novel approach for treatment of primary liver cancer.
Huang LY, Chang CC, Lee YS, Huang JJ, Chuang SH, Chang JM, Kao KJ, Lau GM, Tsai PY, Liu CW, Lin HS, Gish RG, Lau JY. Huang LY, et al. Among authors: huang jj. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20. doi: 10.1007/s00280-014-2540-7. Epub 2014 Jul 20. Cancer Chemother Pharmacol. 2014. PMID: 25038613
Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.
Chuang SH, Lee YE, Huang LYL, Chen CK, Lai CL, Lin YH, Yang JY, Yang SC, Chang LH, Chen CH, Liu CW, Lin HS, Lee YR, Huang KP, Fu KC, Jen HM, Lai JY, Jian PS, Wang YC, Hsueh WY, Tsai PY, Hong WH, Chang CC, Wu DZ, Wu J, Chen MH, Yu KM, Chern CY, Chang JM, Lau JYN, Huang JJ. Chuang SH, et al. Eur J Med Chem. 2020 Apr 1;191:112118. doi: 10.1016/j.ejmech.2020.112118. Epub 2020 Feb 7. Eur J Med Chem. 2020. PMID: 32113126
China Initiative for Multi-Domain Intervention (CHINA-IN-MUDI) to Prevent Cognitive Decline: Study Design and Progress.
Li SY, Xie XY, Liu D, Cheng GR, Hu FF, Zeng DY, Chen XC, Jia LF, Wang YJ, Bu XL, Qiu C, Gao F, Gu JG, Liu MF, Li Y, Zhou YL, Chang HJ, Ou YM, Xu L, Wu ZX, Zhang JJ, Wang JY, Huang LY, Cui YY, Zhou J, Liu XC, Liu J, Nie QQ, Song D, Cai C, Han GB, Yang X, Tan W, Yu JT, Zeng Y. Li SY, et al. Among authors: huang ly. J Prev Alzheimers Dis. 2024;11(3):589-600. doi: 10.14283/jpad.2024.63. J Prev Alzheimers Dis. 2024. PMID: 38706275 Clinical Trial.
782 results