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Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B. Lohman JR, et al. Among authors: huang t, huang sx. Mol Biosyst. 2013 Mar;9(3):478-91. doi: 10.1039/c3mb25523a. Epub 2013 Jan 29. Mol Biosyst. 2013. PMID: 23360970 Free PMC article.
Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.
Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Chang CY, et al. Among authors: huang t. Biochemistry. 2018 Jun 12;57(23):3278-3288. doi: 10.1021/acs.biochem.8b00174. Epub 2018 Mar 21. Biochemistry. 2018. PMID: 29533601 Free PMC article.
Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B. Huang T, et al. J Antibiot (Tokyo). 2016 Oct;69(10):731-740. doi: 10.1038/ja.2016.88. Epub 2016 Jul 13. J Antibiot (Tokyo). 2016. PMID: 27406907 Free PMC article.
Strain Prioritization and Genome Mining for Enediyne Natural Products.
Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Van Nieuwerburgh F, Rader C, Duan Y, Shen B. Yan X, et al. Among authors: huang t, huang y. mBio. 2016 Dec 20;7(6):e02104-16. doi: 10.1128/mBio.02104-16. mBio. 2016. PMID: 27999165 Free PMC article.
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