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410 results

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
House IG, Derrick EB, Sek K, Chen AXY, Li J, Lai J, Todd KL, Munoz I, Michie J, Chan CW, Huang YK, Chan JD, Petley EV, Tong J, Nguyen D, Engel S, Savas P, Hogg SJ, Vervoort SJ, Kearney CJ, Burr ML, Lam EYN, Gilan O, Bedoui S, Johnstone RW, Dawson MA, Loi S, Darcy PK, Beavis PA. House IG, et al. Among authors: huang yk. Cell Rep. 2023 Aug 29;42(8):113014. doi: 10.1016/j.celrep.2023.113014. Epub 2023 Aug 21. Cell Rep. 2023. PMID: 37605534 Free article.
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses.
Todd KL, Lai J, Sek K, Huang YK, Newman DM, Derrick EB, Koay HF, Nguyen D, Hoang TX, Petley EV, Chan CW, Munoz I, House IG, Lee JN, Kim JS, Li J, Tong J, N de Menezes M, Scheffler CM, Yap KM, Chen AXY, Dunbar PA, Haugen B, Parish IA, Johnstone RW, Darcy PK, Beavis PA. Todd KL, et al. Among authors: huang yk. Nat Commun. 2023 Nov 1;14(1):6990. doi: 10.1038/s41467-023-42734-0. Nat Commun. 2023. PMID: 37914685 Free PMC article.
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy.
Chan JD, Scheffler CM, Munoz I, Sek K, Lee JN, Huang YK, Yap KM, Saw NYL, Li J, Chen AXY, Chan CW, Derrick EB, Todd KL, Tong J, Dunbar PA, Li J, Hoang TX, de Menezes MN, Petley EV, Kim JS, Nguyen D, Leung PSK, So J, Deguit C, Zhu J, House IG, Kats LM, Scott AM, Solomon BJ, Harrison SJ, Oliaro J, Parish IA, Quinn KM, Neeson PJ, Slaney CY, Lai J, Beavis PA, Darcy PK. Chan JD, et al. Among authors: huang yk. Nature. 2024 May;629(8010):201-210. doi: 10.1038/s41586-024-07242-1. Epub 2024 Apr 10. Nature. 2024. PMID: 38600376 Free PMC article.
Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.
Kong JCH, Guerra GR, Millen RM, Roth S, Xu H, Neeson PJ, Darcy PK, Kershaw MH, Sampurno S, Malaterre J, Liu DSH, Pham TD, Narasimhan V, Wang M, Huang YK, Visvanathan K, McCormick J, Lynch AC, Warrier S, Michael M, Desai J, Murray W, Mitchell C, Ngan S, Phillips WA, Heriot AG, Ramsay RG. Kong JCH, et al. Among authors: huang yk. JCO Precis Oncol. 2018 Nov;2:1-15. doi: 10.1200/PO.18.00075. JCO Precis Oncol. 2018. PMID: 35135158
High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer.
Wang M, Huang YK, Kong JC, Sun Y, Tantalo DG, Yeang HXA, Ying L, Yan F, Xu D, Halse H, Di Costanzo N, Gordon IR, Mitchell C, Mackay LK, Busuttil RA, Neeson PJ, Boussioutas A. Wang M, et al. Among authors: huang yk. Clin Transl Immunology. 2020 May 5;9(5):e1127. doi: 10.1002/cti2.1127. eCollection 2020 May. Clin Transl Immunology. 2020. PMID: 32377339 Free PMC article.
Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments.
Feng Y, Yang T, Zhu J, Li M, Doyle M, Ozcoban V, Bass GT, Pizzolla A, Cain L, Weng S, Pasam A, Kocovski N, Huang YK, Keam SP, Speed TP, Neeson PJ, Pearson RB, Sandhu S, Goode DL, Trigos AS. Feng Y, et al. Among authors: huang yk. Nat Commun. 2023 May 15;14(1):2697. doi: 10.1038/s41467-023-37822-0. Nat Commun. 2023. PMID: 37188662 Free PMC article.
SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence.
Busuttil RA, George J, House CM, Lade S, Mitchell C, Di Costanzo NS, Pattison S, Huang YK, Tan P, Cheong JH, Rha SY, Boussioutas A. Busuttil RA, et al. Among authors: huang yk. Gastric Cancer. 2021 May;24(3):589-601. doi: 10.1007/s10120-020-01143-8. Epub 2020 Dec 4. Gastric Cancer. 2021. PMID: 33277667 Free PMC article.
Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects.
Li N, Zethoven M, McInerny S, Devereux L, Huang YK, Thio N, Cheasley D, Gutiérrez-Enríquez S, Moles-Fernández A, Diez O, Nguyen-Dumont T, Southey MC, Hopper JL, Simard J, Dumont M, Soucy P, Meindl A, Schmutzler R, Schmidt MK, Adank MA, Andrulis IL, Hahnen E, Engel C, Lesueur F, Girard E, Neuhausen SL, Ziv E, Allen J, Easton DF, Scott RJ, Gorringe KL, James PA, Campbell IG. Li N, et al. Among authors: huang yk. NPJ Breast Cancer. 2021 May 12;7(1):52. doi: 10.1038/s41523-021-00255-3. NPJ Breast Cancer. 2021. PMID: 33980861 Free PMC article.
410 results