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CDP840: a novel inhibitor of PDE-4.
Perry MJ, O'Connell J, Walker C, Crabbe T, Baldock D, Russell A, Lumb S, Huang Z, Howat D, Allen R, Merriman M, Walls J, Daniel T, Hughes B, Laliberte F, Higgs GA, Owens RJ. Perry MJ, et al. Among authors: huang z. Cell Biochem Biophys. 1998;29(1-2):113-32. doi: 10.1007/BF02737831. Cell Biochem Biophys. 1998. PMID: 9631241
Conformational difference between PDE4 apoenzyme and holoenzyme.
Laliberté F, Han Y, Govindarajan A, Giroux A, Liu S, Bobechko B, Lario P, Bartlett A, Gorseth E, Gresser M, Huang Z. Laliberté F, et al. Among authors: huang z. Biochemistry. 2000 May 30;39(21):6449-58. doi: 10.1021/bi992432w. Biochemistry. 2000. PMID: 10828959
Substituted furans as inhibitors of the PDE4 enzyme.
Perrier H, Bayly C, Laliberté F, Huang Z, Rasori R, Robichaud A, Girard Y, Macdonald D. Perrier H, et al. Among authors: huang z. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6. doi: 10.1016/s0960-894x(98)00742-2. Bioorg Med Chem Lett. 1999. PMID: 10091677
L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.
Huang Z, Dias R, Jones T, Liu S, Styhler A, Claveau D, Otu F, Ng K, Laliberte F, Zhang L, Goetghebeur P, Abraham WM, Macdonald D, Dubé D, Gallant M, Lacombe P, Girard Y, Young RN, Turner MJ, Nicholson DW, Mancini JA. Huang Z, et al. Biochem Pharmacol. 2007 Jun 15;73(12):1971-81. doi: 10.1016/j.bcp.2007.03.010. Epub 2007 Mar 16. Biochem Pharmacol. 2007. PMID: 17428447
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