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Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models.
Schultz L, Zurich MG, Culot M, da Costa A, Landry C, Bellwon P, Kristl T, Hörmann K, Ruzek S, Aiche S, Reinert K, Bielow C, Gosselet F, Cecchelli R, Huber CG, Schroeder OH, Gramowski-Voss A, Weiss DG, Bal-Price A. Schultz L, et al. Among authors: huber cg. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):138-65. doi: 10.1016/j.tiv.2015.05.016. Epub 2015 May 27. Toxicol In Vitro. 2015. PMID: 26026931 Free article.
Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.
Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, Hamon J, Carpi D, Ruzek S, Handler A, Schmal O, Herrgen K, Bellwon P, Burek C, Truisi GL, Hewitt P, Di Consiglio E, Testai E, Blaauboer BJ, Guillou C, Huber CG, Lukas A, Pfaller W, Mueller SO, Bois FY, Dekant W, Jennings P. Wilmes A, et al. Among authors: huber cg. J Proteomics. 2013 Feb 21;79:180-94. doi: 10.1016/j.jprot.2012.11.022. Epub 2012 Dec 10. J Proteomics. 2013. PMID: 23238060 Free article.
Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics.
Wilmes A, Bielow C, Ranninger C, Bellwon P, Aschauer L, Limonciel A, Chassaigne H, Kristl T, Aiche S, Huber CG, Guillou C, Hewitt P, Leonard MO, Dekant W, Bois F, Jennings P. Wilmes A, et al. Among authors: huber cg. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27. doi: 10.1016/j.tiv.2014.10.006. Epub 2014 Oct 23. Toxicol In Vitro. 2015. PMID: 25450742
Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline.
Ranninger C, Rurik M, Limonciel A, Ruzek S, Reischl R, Wilmes A, Jennings P, Hewitt P, Dekant W, Kohlbacher O, Huber CG. Ranninger C, et al. Among authors: huber cg. J Biol Chem. 2015 Jul 31;290(31):19121-32. doi: 10.1074/jbc.M115.644146. Epub 2015 Jun 8. J Biol Chem. 2015. PMID: 26055719 Free PMC article.
Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components.
Boyles MS, Kristl T, Andosch A, Zimmermann M, Tran N, Casals E, Himly M, Puntes V, Huber CG, Lütz-Meindl U, Duschl A. Boyles MS, et al. Among authors: huber cg. J Nanobiotechnology. 2015 Nov 18;13:84. doi: 10.1186/s12951-015-0146-9. J Nanobiotechnology. 2015. PMID: 26582370 Free PMC article.
320 results