Hudson BD - Search Results

1

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G. Hudson BD, et al. Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26. Mol Pharmacol. 2013. PMID: 23979972 Free PMC article.

2

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G. Jenkins L, et al. Among authors: hudson bd. Biochem J. 2010 Dec 15;432(3):451-9. doi: 10.1042/BJ20101287. Biochem J. 2010. PMID: 20919992

3

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: hudson bd. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.

4

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.

Smith NJ, Ward RJ, Stoddart LA, Hudson BD, Kostenis E, Ulven T, Morris JC, Tränkle C, Tikhonova IG, Adams DR, Milligan G. Smith NJ, et al. Among authors: hudson bd. Mol Pharmacol. 2011 Jul;80(1):163-73. doi: 10.1124/mol.110.070789. Epub 2011 Apr 15. Mol Pharmacol. 2011. PMID: 21498659 Free PMC article.

5

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

Hudson BD, Smith NJ, Milligan G. Hudson BD, et al. Adv Pharmacol. 2011;62:175-218. doi: 10.1016/B978-0-12-385952-5.00006-3. Adv Pharmacol. 2011. PMID: 21907910 Review.

6

Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor.

Terhzaz S, Cabrero P, Robben JH, Radford JC, Hudson BD, Milligan G, Dow JA, Davies SA. Terhzaz S, et al. Among authors: hudson bd. PLoS One. 2012;7(1):e29897. doi: 10.1371/journal.pone.0029897. Epub 2012 Jan 11. PLoS One. 2012. PMID: 22253819 Free PMC article.

7

Discovery of a potent and selective GPR120 agonist.

Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T. Shimpukade B, et al. Among authors: hudson bd. J Med Chem. 2012 May 10;55(9):4511-5. doi: 10.1021/jm300215x. Epub 2012 May 2. J Med Chem. 2012. PMID: 22519963

8

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schröder R, Hudson BD, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: hudson bd. J Med Chem. 2012 Jul 26;55(14):6624-8. doi: 10.1021/jm3002026. Epub 2012 Jul 13. J Med Chem. 2012. PMID: 22724451

9

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

Hudson BD, Christiansen E, Tikhonova IG, Grundmann M, Kostenis E, Adams DR, Ulven T, Milligan G. Hudson BD, et al. FASEB J. 2012 Dec;26(12):4951-65. doi: 10.1096/fj.12-213314. Epub 2012 Aug 23. FASEB J. 2012. PMID: 22919070 Free PMC article.

10

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

Hudson BD, Tikhonova IG, Pandey SK, Ulven T, Milligan G. Hudson BD, et al. J Biol Chem. 2012 Nov 30;287(49):41195-209. doi: 10.1074/jbc.M112.396259. Epub 2012 Oct 12. J Biol Chem. 2012. PMID: 23066016 Free PMC article.

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