Humphries RG - Search Results

1

P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors.

Fagura MS, Dainty IA, McKay GD, Kirk IP, Humphries RG, Robertson MJ, Dougall IG, Leff P. Fagura MS, et al. Among authors: humphries rg. Br J Pharmacol. 1998 May;124(1):157-64. doi: 10.1038/sj.bjp.0701827. Br J Pharmacol. 1998. PMID: 9630355 Free PMC article.

2

Pharmacological profile of the novel P2T-purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo.

Humphries RG, Tomlinson W, Clegg JA, Ingall AH, Kindon ND, Leff P. Humphries RG, et al. Br J Pharmacol. 1995 Jul;115(6):1110-6. doi: 10.1111/j.1476-5381.1995.tb15925.x. Br J Pharmacol. 1995. PMID: 7582510 Free PMC article.

3

FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors.

Humphries RG, Tomlinson W, Ingall AH, Cage PA, Leff P. Humphries RG, et al. Br J Pharmacol. 1994 Nov;113(3):1057-63. doi: 10.1111/j.1476-5381.1994.tb17100.x. Br J Pharmacol. 1994. PMID: 7858849 Free PMC article.

4

ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors.

Jarvis GE, Humphries RG, Robertson MJ, Leff P. Jarvis GE, et al. Among authors: humphries rg. Br J Pharmacol. 2000 Jan;129(2):275-82. doi: 10.1038/sj.bjp.0703046. Br J Pharmacol. 2000. PMID: 10694233 Free PMC article.

5

The C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptor.

Jin J, Tomlinson W, Kirk IP, Kim YB, Humphries RG, Kunapuli SP. Jin J, et al. Among authors: humphries rg. Br J Pharmacol. 2001 Jun;133(4):521-8. doi: 10.1038/sj.bjp.0704114. Br J Pharmacol. 2001. PMID: 11399669 Free PMC article.

6

Inhibition of collagen- and ADP-induced platelet aggregation by substance P in vivo: involvement of endothelium-derived relaxing factor.

Humphries RG, Tomlinson W, O'Connor SE, Leff P. Humphries RG, et al. J Cardiovasc Pharmacol. 1990 Aug;16(2):292-7. doi: 10.1097/00005344-199008000-00016. J Cardiovasc Pharmacol. 1990. PMID: 1697386

7

A novel series of P2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis.

Humphries RG, Robertson MJ, Leff P. Humphries RG, et al. Trends Pharmacol Sci. 1995 Jun;16(6):179-81. doi: 10.1016/s0165-6147(00)89018-5. Trends Pharmacol Sci. 1995. PMID: 7652925 Review. No abstract available.

8

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Among authors: humphries rg. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008

9

Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy.

Ingall AH, Dixon J, Bailey A, Coombs ME, Cox D, McInally JI, Hunt SF, Kindon ND, Teobald BJ, Willis PA, Humphries RG, Leff P, Clegg JA, Smith JA, Tomlinson W. Ingall AH, et al. Among authors: humphries rg. J Med Chem. 1999 Jan 28;42(2):213-20. doi: 10.1021/jm981072s. J Med Chem. 1999. PMID: 9925726

10

Coronary vasoconstriction in the conscious rabbit following intravenous infusion of L-NG-nitro-arginine.

Humphries RG, Carr RD, Nicol AK, Tomlinson W, O'Connor SE. Humphries RG, et al. Br J Pharmacol. 1991 Mar;102(3):565-6. doi: 10.1111/j.1476-5381.1991.tb12212.x. Br J Pharmacol. 1991. PMID: 1364819 Free PMC article.

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