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Neuron-astrocyte transmitophagy is altered in Alzheimer's disease.
Lampinen R, Belaya I, Saveleva L, Liddell JR, Rait D, Huuskonen MT, Giniatullina R, Sorvari A, Soppela L, Mikhailov N, Boccuni I, Giniatullin R, Cruz-Haces M, Konovalova J, Koskuvi M, Domanskyi A, Hämäläinen RH, Goldsteins G, Koistinaho J, Malm T, Chew S, Rilla K, White AR, Marsh-Armstrong N, Kanninen KM. Lampinen R, et al. Among authors: huuskonen mt. Neurobiol Dis. 2022 Aug;170:105753. doi: 10.1016/j.nbd.2022.105753. Epub 2022 May 13. Neurobiol Dis. 2022. PMID: 35569719 Free article.
PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.
Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T. Konttinen H, et al. Among authors: huuskonen mt. Glia. 2019 Jan;67(1):146-159. doi: 10.1002/glia.23534. Epub 2018 Nov 19. Glia. 2019. PMID: 30453390 Free PMC article.
CuII(atsm) Attenuates Neuroinflammation.
Choo XY, Liddell JR, Huuskonen MT, Grubman A, Moujalled D, Roberts J, Kysenius K, Patten L, Quek H, Oikari LE, Duncan C, James SA, McInnes LE, Hayne DJ, Donnelly PS, Pollari E, Vähätalo S, Lejavová K, Kettunen MI, Malm T, Koistinaho J, White AR, Kanninen KM. Choo XY, et al. Among authors: huuskonen mt. Front Neurosci. 2018 Sep 24;12:668. doi: 10.3389/fnins.2018.00668. eCollection 2018. Front Neurosci. 2018. PMID: 30319344 Free PMC article.
The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.
Huuskonen MT, Tuo QZ, Loppi S, Dhungana H, Korhonen P, McInnes LE, Donnelly PS, Grubman A, Wojciechowski S, Lejavova K, Pomeshchik Y, Periviita L, Kosonen L, Giordano M, Walker FR, Liu R, Bush AI, Koistinaho J, Malm T, White AR, Lei P, Kanninen KM. Huuskonen MT, et al. Neurotherapeutics. 2017 Apr;14(2):519-532. doi: 10.1007/s13311-016-0504-9. Neurotherapeutics. 2017. PMID: 28050710 Free PMC article.
Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice.
Singh Y, Leinonen H, Fazaludeen F, Jaronen M, Guest D, Buckley N, Byts N, Oksa P, Jalkanen K, Iqbal I, Huuskonen M, Savchenko E, Keksa-Goldsteine V, Chew S, Myllyharju J, Tanila H, Ooi L, Koistinaho J, Kanninen KM, Malm T. Singh Y, et al. Hum Mol Genet. 2019 Oct 1;28(19):3309-3322. doi: 10.1093/hmg/ddz165. Hum Mol Genet. 2019. PMID: 31294445
Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation.
Kolosowska N, Gotkiewicz M, Dhungana H, Giudice L, Giugno R, Box D, Huuskonen MT, Korhonen P, Scoyni F, Kanninen KM, Ylä-Herttuala S, Turunen TA, Turunen MP, Koistinaho J, Malm T. Kolosowska N, et al. Among authors: huuskonen mt. J Neuroinflammation. 2020 Jun 19;17(1):194. doi: 10.1186/s12974-020-01870-w. J Neuroinflammation. 2020. PMID: 32560730 Free PMC article.
Lack of collagen XV is protective after ischemic stroke in mice.
Dhungana H, Huuskonen MT, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen KM, Malm T, Koistinaho J, Lemarchant S. Dhungana H, et al. Among authors: huuskonen mt. Cell Death Dis. 2017 Jan 12;8(1):e2541. doi: 10.1038/cddis.2016.456. Cell Death Dis. 2017. PMID: 28079884 Free PMC article.
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage.
Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, Hanhineva K, Kanninen K, Malm T. Loppi S, et al. Brain Behav Immun. 2018 Oct;73:670-681. doi: 10.1016/j.bbi.2018.07.021. Epub 2018 Jul 29. Brain Behav Immun. 2018. PMID: 30063972 Free PMC article.
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. Martiskainen H, et al. J Neuroinflammation. 2017 Nov 7;14(1):215. doi: 10.1186/s12974-017-0991-6. J Neuroinflammation. 2017. PMID: 29115990 Free PMC article.
31 results