Hwang TH - Search Results

1

Pexa-Vec double agent engineered vaccinia: oncolytic and active immunotherapeutic.

Breitbach CJ, Parato K, Burke J, Hwang TH, Bell JC, Kirn DH. Breitbach CJ, et al. Among authors: hwang th. Curr Opin Virol. 2015 Aug;13:49-54. doi: 10.1016/j.coviro.2015.03.016. Epub 2015 Apr 17. Curr Opin Virol. 2015. PMID: 25900822 Review.

2

Vaccinia virus and oncolytic virotherapy of cancer.

Thorne SH, Hwang TH, Kirn DH. Thorne SH, et al. Among authors: hwang th. Curr Opin Mol Ther. 2005 Aug;7(4):359-65. Curr Opin Mol Ther. 2005. PMID: 16121702 Review.

3

Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963.

Thorne SH, Hwang TH, O'Gorman WE, Bartlett DL, Sei S, Kanji F, Brown C, Werier J, Cho JH, Lee DE, Wang Y, Bell J, Kirn DH. Thorne SH, et al. Among authors: hwang th. J Clin Invest. 2007 Nov;117(11):3350-8. doi: 10.1172/JCI32727. J Clin Invest. 2007. PMID: 17965776 Free PMC article.

4

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial.

Park BH, Hwang T, Liu TC, Sze DY, Kim JS, Kwon HC, Oh SY, Han SY, Yoon JH, Hong SH, Moon A, Speth K, Park C, Ahn YJ, Daneshmand M, Rhee BG, Pinedo HM, Bell JC, Kirn DH. Park BH, et al. Lancet Oncol. 2008 Jun;9(6):533-42. doi: 10.1016/S1470-2045(08)70107-4. Epub 2008 May 19. Lancet Oncol. 2008. PMID: 18495536 Clinical Trial.

5

Translation of targeted oncolytic virotherapeutics from the lab into the clinic, and back again: a high-value iterative loop.

Liu TC, Hwang TH, Bell JC, Kirn DH. Liu TC, et al. Among authors: hwang th. Mol Ther. 2008 Jun;16(6):1006-8. doi: 10.1038/mt.2008.70. Mol Ther. 2008. PMID: 18500240 Free article. No abstract available.

6

The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma.

Liu TC, Hwang T, Park BH, Bell J, Kirn DH. Liu TC, et al. Mol Ther. 2008 Sep;16(9):1637-42. doi: 10.1038/mt.2008.143. Epub 2008 Jul 15. Mol Ther. 2008. PMID: 18628758 Free article.

7

Development of targeted oncolytic virotherapeutics through translational research.

Liu TC, Hwang TH, Bell JC, Kirn DH. Liu TC, et al. Among authors: hwang th. Expert Opin Biol Ther. 2008 Sep;8(9):1381-91. doi: 10.1517/14712598.8.9.1381. Expert Opin Biol Ther. 2008. PMID: 18694356 Review.

8

Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy.

Heo J, Breitbach CJ, Moon A, Kim CW, Patt R, Kim MK, Lee YK, Oh SY, Woo HY, Parato K, Rintoul J, Falls T, Hickman T, Rhee BG, Bell JC, Kirn DH, Hwang TH. Heo J, et al. Among authors: hwang th. Mol Ther. 2011 Jun;19(6):1170-9. doi: 10.1038/mt.2011.39. Epub 2011 Mar 22. Mol Ther. 2011. PMID: 21427706 Free PMC article.

9

A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma.

Hwang TH, Moon A, Burke J, Ribas A, Stephenson J, Breitbach CJ, Daneshmand M, De Silva N, Parato K, Diallo JS, Lee YS, Liu TC, Bell JC, Kirn DH. Hwang TH, et al. Mol Ther. 2011 Oct;19(10):1913-22. doi: 10.1038/mt.2011.132. Epub 2011 Jul 19. Mol Ther. 2011. PMID: 21772252 Free PMC article. Clinical Trial.

10

Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans.

Breitbach CJ, Burke J, Jonker D, Stephenson J, Haas AR, Chow LQ, Nieva J, Hwang TH, Moon A, Patt R, Pelusio A, Le Boeuf F, Burns J, Evgin L, De Silva N, Cvancic S, Robertson T, Je JE, Lee YS, Parato K, Diallo JS, Fenster A, Daneshmand M, Bell JC, Kirn DH. Breitbach CJ, et al. Among authors: hwang th. Nature. 2011 Aug 31;477(7362):99-102. doi: 10.1038/nature10358. Nature. 2011. PMID: 21886163 Clinical Trial.

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