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7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex.
Nguyen W, Dans MG, Currie I, Awalt JK, Bailey BL, Lumb C, Ngo A, Favuzza P, Palandri J, Ramesh S, Penington J, Jarman KE, Mukherjee P, Chakraborty A, Maier AG, van Dooren GG, Papenfuss T, Wittlin S, Churchyard A, Baum J, Winzeler EA, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Nguyen W, et al. Among authors: currie i. ACS Infect Dis. 2023 Mar 10;9(3):668-691. doi: 10.1021/acsinfecdis.2c00607. Epub 2023 Feb 28. ACS Infect Dis. 2023. PMID: 36853190 Free PMC article.
Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells.
Kim ML, Hardy MY, Edgington-Mitchell LE, Ramarathinam SH, Chung SZ, Russell AK, Currie I, Sleebs BE, Purcell AW, Tye-Din JA, Wicks IP. Kim ML, et al. Among authors: currie i. iScience. 2021 Nov 25;24(12):103509. doi: 10.1016/j.isci.2021.103509. eCollection 2021 Dec 17. iScience. 2021. PMID: 34934928 Free PMC article.