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Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis.
Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2301252120. doi: 10.1073/pnas.2301252120. Epub 2023 May 1.
Proc Natl Acad Sci U S A. 2023.
PMID: 37126691
Free PMC article.
Relationship Between Sporadic Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders: A Study in Families.
Icho S, Korten N, Reus L, Belderok T, Krudop W, Gossink F, van Ruissen F, Cohn-Hokke P, Feller R, van Swieten J, Dols A, Pijnenburg Y.
Icho S, et al.
J Clin Psychiatry. 2022 Nov 2;83(6):21m13932. doi: 10.4088/JCP.21m13932.
J Clin Psychiatry. 2022.
PMID: 36321927
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Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells.
Icho S, Rujas E, Muthuraman K, Tam J, Liang H, Landreth S, Liao M, Falzarano D, Julien JP, Melnyk RA.
Icho S, et al.
Antimicrob Agents Chemother. 2022 Jul 19;66(7):e0043922. doi: 10.1128/aac.00439-22. Epub 2022 Jun 15.
Antimicrob Agents Chemother. 2022.
PMID: 35703551
Free PMC article.
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Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin.
Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA.
Tam J, et al. Among authors: icho s.
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6792-6800. doi: 10.1073/pnas.1916965117. Epub 2020 Mar 9.
Proc Natl Acad Sci U S A. 2020.
PMID: 32152097
Free PMC article.
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Dismantling a Toxin to Disarm a Superbug.
Icho S, Melnyk RA.
Icho S, et al.
Trends Pharmacol Sci. 2019 Mar;40(3):155-156. doi: 10.1016/j.tips.2019.01.007. Epub 2019 Jan 23.
Trends Pharmacol Sci. 2019.
PMID: 30685063
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