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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.
Yoshida J, Ohishi T, Abe H, Ohba SI, Inoue H, Usami I, Amemiya M, Oriez R, Sakashita C, Dan S, Sugawara M, Kawaguchi T, Ueno J, Asano Y, Ikeda A, Takamatsu M, Amori G, Kondoh Y, Honda K, Osada H, Noda T, Watanabe T, Shimizu T, Shibasaki M, Kawada M. Yoshida J, et al. Among authors: usami i. iScience. 2021 Nov 25;24(12):103497. doi: 10.1016/j.isci.2021.103497. eCollection 2021 Dec 17. iScience. 2021. PMID: 34934919 Free PMC article.
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. Kawada M, et al. Among authors: usami i. PLoS One. 2015 Mar 18;10(3):e0119415. doi: 10.1371/journal.pone.0119415. eCollection 2015. PLoS One. 2015. PMID: 25785838 Free PMC article.
NBRI17671, a new antitumor compound, produced by Acremonium sp. CR17671.
Kawada M, Usami I, Someno T, Watanabe T, Abe H, Inoue H, Ohba S, Masuda T, Tabata Y, Yamaguchi S, Ikeda D. Kawada M, et al. Among authors: usami i. J Antibiot (Tokyo). 2010 May;63(5):237-43. doi: 10.1038/ja.2010.28. Epub 2010 Apr 9. J Antibiot (Tokyo). 2010. PMID: 20379217