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Page 1
Current status and future perspectives in targeted therapy of NPM1-mutated AML.
Ranieri R, Pianigiani G, Sciabolacci S, Perriello VM, Marra A, Cardinali V, Pierangeli S, Milano F, Gionfriddo I, Brunetti L, Martelli MP, Falini B. Ranieri R, et al. Among authors: gionfriddo i. Leukemia. 2022 Oct;36(10):2351-2367. doi: 10.1038/s41375-022-01666-2. Epub 2022 Aug 25. Leukemia. 2022. PMID: 36008542 Free PMC article. Review.
Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA. Brunetti L, et al. Among authors: gionfriddo i. Cancer Cell. 2018 Sep 10;34(3):499-512.e9. doi: 10.1016/j.ccell.2018.08.005. Cancer Cell. 2018. PMID: 30205049 Free PMC article.
CD123 Is Consistently Expressed on NPM1-Mutated AML Cells.
Perriello VM, Gionfriddo I, Rossi R, Milano F, Mezzasoma F, Marra A, Spinelli O, Rambaldi A, Annibali O, Avvisati G, Di Raimondo F, Ascani S, Falini B, Martelli MP, Brunetti L. Perriello VM, et al. Among authors: gionfriddo i. Cancers (Basel). 2021 Jan 28;13(3):496. doi: 10.3390/cancers13030496. Cancers (Basel). 2021. PMID: 33525388 Free PMC article.
Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.
Gionfriddo I, Brunetti L, Mezzasoma F, Milano F, Cardinali V, Ranieri R, Venanzi A, Pierangeli S, Vetro C, Spinozzi G, Dorillo E, Wu HC, Berthier C, Ciurnelli R, Griffin MJ, Jennings CE, Tiacci E, Sportoletti P, Falzetti F, de Thé H, Veal GJ, Martelli MP, Falini B. Gionfriddo I, et al. Leukemia. 2021 Sep;35(9):2552-2562. doi: 10.1038/s41375-021-01192-7. Epub 2021 Mar 2. Leukemia. 2021. PMID: 33654209 Free PMC article. Clinical Trial.
Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML.
Martelli MP, Rossi R, Venanzi A, Meggendorfer M, Perriello VM, Martino G, Spinelli O, Ciurnelli R, Varasano E, Brunetti L, Ascani S, Quadalti C, Cardinali V, Mezzasoma F, Gionfriddo I, Milano F, Pacini R, Tabarrini A, Bigerna B, Albano F, Specchia G, Vetro C, Di Raimondo F, Annibali O, Avvisati G, Rambaldi A, Falzetti F, Tiacci E, Sportoletti P, Haferlach T, Haferlach C, Falini B. Martelli MP, et al. Among authors: gionfriddo i. Blood. 2021 Dec 23;138(25):2696-2701. doi: 10.1182/blood.2021012732. Blood. 2021. PMID: 34343258 Free PMC article.
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Sportoletti P, Varasano E, Rossi R, Bereshchenko O, Cecchini D, Gionfriddo I, Bolli N, Tiacci E, Intermesoli T, Zanghì P, Masciulli A, Martelli MP, Falzetti F, Martelli MF, Falini B. Sportoletti P, et al. Among authors: gionfriddo i. Blood. 2013 Apr 25;121(17):3447-58. doi: 10.1182/blood-2012-08-449553. Epub 2013 Feb 22. Blood. 2013. PMID: 23435463 Free article.
Human papillomavirus type 77 E7 protein is a weak deregulator of cell cycle.
Mansour M, Touka M, Malena A, Indiveri C, Dong W, Gionfriddo I, Accardi R, Paradiso A, Sylla BS, Gabet AS, Tommasino M. Mansour M, et al. Among authors: gionfriddo i. Cancer Lett. 2007 Feb 8;246(1-2):274-81. doi: 10.1016/j.canlet.2006.03.006. Epub 2006 May 2. Cancer Lett. 2007. PMID: 16650526
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
Martelli MP, Gionfriddo I, Mezzasoma F, Milano F, Pierangeli S, Mulas F, Pacini R, Tabarrini A, Pettirossi V, Rossi R, Vetro C, Brunetti L, Sportoletti P, Tiacci E, Di Raimondo F, Falini B. Martelli MP, et al. Among authors: gionfriddo i. Blood. 2015 May 28;125(22):3455-65. doi: 10.1182/blood-2014-11-611459. Epub 2015 Mar 20. Blood. 2015. PMID: 25795919 Free article.
11 results