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Page 1
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome.
Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE. Rom O, et al. Among authors: mor i. Sci Transl Med. 2020 Dec 2;12(572):eaaz2841. doi: 10.1126/scitranslmed.aaz2841. Sci Transl Med. 2020. PMID: 33268508 Free PMC article.
Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Ghrayeb A, et al. Among authors: mor i. Cell Metab. 2024 Jan 2;36(1):116-129.e7. doi: 10.1016/j.cmet.2023.12.013. Cell Metab. 2024. PMID: 38171331
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.
Rom O, Liu Y, Finney AC, Ghrayeb A, Zhao Y, Shukha Y, Wang L, Rajanayake KK, Das S, Rashdan NA, Weissman N, Delgadillo L, Wen B, Garcia-Barrio MT, Aviram M, Kevil CG, Yurdagul A Jr, Pattillo CB, Zhang J, Sun D, Hayek T, Gottlieb E, Mor I, Chen YE. Rom O, et al. Among authors: mor i. Redox Biol. 2022 Jun;52:102313. doi: 10.1016/j.redox.2022.102313. Epub 2022 Apr 13. Redox Biol. 2022. PMID: 35447412 Free PMC article.
Metabolic regulation by p53 family members.
Berkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH. Berkers CR, et al. Among authors: mor i. Cell Metab. 2013 Nov 5;18(5):617-33. doi: 10.1016/j.cmet.2013.06.019. Epub 2013 Aug 15. Cell Metab. 2013. PMID: 23954639 Free PMC article. Review.
Alcohol-derived acetate modulates brain function.
Ghrayeb A, Gottlieb E, Mor I. Ghrayeb A, et al. Among authors: mor i. Nat Metab. 2019 Nov;1(11):1036-1037. doi: 10.1038/s42255-019-0139-3. Nat Metab. 2019. PMID: 32694859 No abstract available.
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.
Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov S, MacKay G, Kamphorst JJ, Herzyk P, Fernández-García J, Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross JR, Kharas MG, Gottlieb E, Izraeli S, Halsey C. Savino AM, et al. Among authors: mor i. Nat Cancer. 2020 Oct;1(10):998-1009. doi: 10.1038/s43018-020-00115-2. Epub 2020 Sep 28. Nat Cancer. 2020. PMID: 33479702 Free PMC article.
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