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2020 1
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2023 5
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Page 1
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Among authors: heckenbach i. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
Spatial mapping of cellular senescence: emerging challenges and opportunities.
Gurkar AU, Gerencser AA, Mora AL, Nelson AC, Zhang AR, Lagnado AB, Enninful A, Benz C, Furman D, Beaulieu D, Jurk D, Thompson EL, Wu F, Rodriguez F, Barthel G, Chen H, Phatnani H, Heckenbach I, Chuang JH, Horrell J, Petrescu J, Alder JK, Lee JH, Niedernhofer LJ, Kumar M, Königshoff M, Bueno M, Sokka M, Scheibye-Knudsen M, Neretti N, Eickelberg O, Adams PD, Hu Q, Zhu Q, Porritt RA, Dong R, Peters S, Victorelli S, Pengo T, Khaliullin T, Suryadevara V, Fu X, Bar-Joseph Z, Ji Z, Passos JF. Gurkar AU, et al. Among authors: heckenbach i. Nat Aging. 2023 Jul;3(7):776-790. doi: 10.1038/s43587-023-00446-6. Epub 2023 Jul 3. Nat Aging. 2023. PMID: 37400722 Free PMC article. Review.
Tracking the dynamics of cellular senescence.
Heckenbach I, Scheibye-Knudsen M. Heckenbach I, et al. Aging (Albany NY). 2023 Apr 17;15(9):3219-3220. doi: 10.18632/aging.204670. Epub 2023 Apr 17. Aging (Albany NY). 2023. PMID: 37071012 Free PMC article. No abstract available.
Nuclear morphology is a deep learning biomarker of cellular senescence.
Heckenbach I, Mkrtchyan GV, Ezra MB, Bakula D, Madsen JS, Nielsen MH, Oró D, Osborne B, Covarrubias AJ, Idda ML, Gorospe M, Mortensen L, Verdin E, Westendorp R, Scheibye-Knudsen M. Heckenbach I, et al. Nat Aging. 2022 Aug;2(8):742-755. doi: 10.1038/s43587-022-00263-3. Epub 2022 Aug 15. Nat Aging. 2022. PMID: 37118134 Free PMC article.
Histone malonylation is regulated by SIRT5 and KAT2A.
Zhang R, Bons J, Scheidemantle G, Liu X, Bielska O, Carrico C, Rose J, Heckenbach I, Scheibye-Knudsen M, Schilling B, Verdin E. Zhang R, et al. Among authors: heckenbach i. iScience. 2023 Feb 13;26(3):106193. doi: 10.1016/j.isci.2023.106193. eCollection 2023 Mar 17. iScience. 2023. PMID: 36879797 Free PMC article.
CD38 regulates ovarian function and fecundity via NAD+ metabolism.
Perrone R, Ashok Kumaar PV, Haky L, Hahn C, Riley R, Balough J, Zaza G, Soygur B, Hung K, Prado L, Kasler HG, Tiwari R, Matsui H, Hormazabal GV, Heckenbach I, Scheibye-Knudsen M, Duncan FE, Verdin E. Perrone R, et al. Among authors: heckenbach i. iScience. 2023 Sep 16;26(10):107949. doi: 10.1016/j.isci.2023.107949. eCollection 2023 Oct 20. iScience. 2023. PMID: 37822499 Free PMC article.
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.
Herman AB, Anerillas C, Harris SC, Munk R, Martindale JL, Yang X, Mazan-Mamczarz K, Zhang Y, Heckenbach IJ, Scheibye-Knudsen M, De S, Sen P, Abdelmohsen K, Gorospe M. Herman AB, et al. Among authors: heckenbach ij. Nucleic Acids Res. 2021 Jul 21;49(13):7389-7405. doi: 10.1093/nar/gkab538. Nucleic Acids Res. 2021. PMID: 34181735 Free PMC article.
Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Among authors: heckenbach i. Nat Metab. 2021 Jan;3(1):120-121. doi: 10.1038/s42255-020-00328-w. Nat Metab. 2021. PMID: 33303985 No abstract available.