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From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Among authors: ingall ah. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008
P2T purinoceptor antagonists. A QSAR study of some 2-substituted ATP analogues.
Tomkinson NP, Marriott DP, Cage PA, Cox D, Davis AM, Flower DR, Gensmantel NP, Humphries RG, Ingall AH, Kindon ND. Tomkinson NP, et al. Among authors: ingall ah. J Pharm Pharmacol. 1996 Feb;48(2):206-9. doi: 10.1111/j.2042-7158.1996.tb07124.x. J Pharm Pharmacol. 1996. PMID: 8935173
The medicinal chemistry of the P2 receptor family.
Guile SD, Ince F, Ingall AH, Kindon ND, Meghani P, Mortimore MP. Guile SD, et al. Among authors: ingall ah. Prog Med Chem. 2001;38:115-87. doi: 10.1016/s0079-6468(08)70093-6. Prog Med Chem. 2001. PMID: 11774794 Review. No abstract available.
Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists.
Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Connolly S, Cook A, Fisher A, Flaherty A, Hill S, Humphries A, Ingall A, Jordan S, Lawson M, Mullen A, Nicholls D, Paine S, Pairaudeau G, St-Gallay S, Young A. Stocks MJ, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4027-31. doi: 10.1016/j.bmcl.2011.04.135. Epub 2011 May 20. Bioorg Med Chem Lett. 2011. PMID: 21652207
Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action.
Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Dixon J, Connolly S, Cook A, Fisher A, Flaherty A, Humphries A, Ingall A, Jordan S, Lawson M, Mullen A, Nicholls D, Paine S, Pairaudeau G, Young A. Stocks MJ, et al. ACS Med Chem Lett. 2014 Feb 8;5(4):416-21. doi: 10.1021/ml4005232. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900851 Free PMC article.
15 results