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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, Irwin MS, Lee JE, Tsao MS, Raught B, Marshall CB, Ohh M, Ikura M. Gebregiworgis T, et al. Among authors: irwin ms. Nat Commun. 2021 Nov 1;12(1):6274. doi: 10.1038/s41467-021-26526-y. Nat Commun. 2021. PMID: 34725361 Free PMC article.
Expression of p53 in renal carcinoma cells is independent of pVHL.
Stickle NH, Cheng LS, Watson IR, Alon N, Malkin D, Irwin MS, Ohh M. Stickle NH, et al. Among authors: irwin ms. Mutat Res. 2005 Oct 15;578(1-2):23-32. doi: 10.1016/j.mrfmmm.2005.02.016. Epub 2005 Jul 5. Mutat Res. 2005. PMID: 15998523
Regulation of endocytosis via the oxygen-sensing pathway.
Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, Marsden PA, Ohh M. Wang Y, et al. Among authors: irwin ms. Nat Med. 2009 Mar;15(3):319-24. doi: 10.1038/nm.1922. Epub 2009 Mar 1. Nat Med. 2009. PMID: 19252501
Chemotherapy induces NEDP1-mediated destabilization of MDM2.
Watson IR, Li BK, Roche O, Blanch A, Ohh M, Irwin MS. Watson IR, et al. Among authors: irwin ms. Oncogene. 2010 Jan 14;29(2):297-304. doi: 10.1038/onc.2009.314. Epub 2009 Sep 28. Oncogene. 2010. PMID: 19784069
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.
Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. Chung J, et al. Among authors: irwin ms. EMBO Rep. 2010 Oct;11(10):777-83. doi: 10.1038/embor.2010.125. Epub 2010 Sep 10. EMBO Rep. 2010. PMID: 20829881 Free PMC article.
NEDD8 pathways in cancer, Sine Quibus Non.
Watson IR, Irwin MS, Ohh M. Watson IR, et al. Among authors: irwin ms. Cancer Cell. 2011 Feb 15;19(2):168-76. doi: 10.1016/j.ccr.2011.01.002. Cancer Cell. 2011. PMID: 21316600 Free article. Review.
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M. Wang Y, et al. Among authors: irwin ms. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4892-7. doi: 10.1073/pnas.1112129109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411794 Free PMC article.
144 results