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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling.
Cell Chem Biol. 2023 Jan 19;30(1):43-54.e8. doi: 10.1016/j.chembiol.2022.11.012. Epub 2022 Dec 17.
Cell Chem Biol. 2023.
PMID: 36529140
Free PMC article.
Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor.
Bejan DS, Sundalam S, Jin H, Morgan RK, Kirby IT, Siordia IR, Tivon B, London N, Cohen MS.
Bejan DS, et al. Among authors: siordia ir.
Chem Sci. 2022 Nov 16;13(46):13898-13906. doi: 10.1039/d2sc04820e. eCollection 2022 Nov 30.
Chem Sci. 2022.
PMID: 36544740
Free PMC article.
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Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.
Rodriguez KM, Buch-Larsen SC, Kirby IT, Siordia IR, Hutin D, Rasmussen M, Grant DM, David LL, Matthews J, Nielsen ML, Cohen MS.
Rodriguez KM, et al. Among authors: siordia ir.
Elife. 2021 Jan 21;10:e60480. doi: 10.7554/eLife.60480.
Elife. 2021.
PMID: 33475084
Free PMC article.
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