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An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation.
Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, Vargas J, Boyle S, Fazelinia H, Qian L, Suresh K, Taylor D, Paton JC, Paton AW, Tang CA, Hu CA, Radhakrishnan R, Gidalevitz T, Argon Y. Ricci D, et al. Among authors: vargas j. J Biol Chem. 2021 Jan-Jun;296:100781. doi: 10.1016/j.jbc.2021.100781. Epub 2021 May 14. J Biol Chem. 2021. PMID: 34000298 Free PMC article.
Clustering of IRE1α depends on sensing ER stress but not on its RNase activity.
Ricci D, Marrocco I, Blumenthal D, Dibos M, Eletto D, Vargas J, Boyle S, Iwamoto Y, Chomistek S, Paton JC, Paton AW, Argon Y. Ricci D, et al. Among authors: vargas j. FASEB J. 2019 Sep;33(9):9811-9827. doi: 10.1096/fj.201801240RR. Epub 2019 Jun 14. FASEB J. 2019. PMID: 31199681 Free PMC article.