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Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.
Lai AC, Toure M, Hellerschmied D, Salami J, Jaime-Figueroa S, Ko E, Hines J, Crews CM. Lai AC, et al. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10. doi: 10.1002/anie.201507634. Epub 2015 Nov 23. Angew Chem Int Ed Engl. 2016. PMID: 26593377 Free PMC article.
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.
Burslem GM, Smith BE, Lai AC, Jaime-Figueroa S, McQuaid DC, Bondeson DP, Toure M, Dong H, Qian Y, Wang J, Crew AP, Hines J, Crews CM. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. doi: 10.1016/j.chembiol.2017.09.009. Epub 2017 Nov 9. Cell Chem Biol. 2018. PMID: 29129716 Free PMC article.
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
Bondeson DP, Smith BE, Burslem GM, Buhimschi AD, Hines J, Jaime-Figueroa S, Wang J, Hamman BD, Ishchenko A, Crews CM. Bondeson DP, et al. Among authors: jaime figueroa s. Cell Chem Biol. 2018 Jan 18;25(1):78-87.e5. doi: 10.1016/j.chembiol.2017.09.010. Epub 2017 Nov 9. Cell Chem Biol. 2018. PMID: 29129718 Free PMC article.
Mutant-selective degradation by BRAF-targeting PROTACs.
Alabi S, Jaime-Figueroa S, Yao Z, Gao Y, Hines J, Samarasinghe KTG, Vogt L, Rosen N, Crews CM. Alabi S, et al. Among authors: jaime figueroa s. Nat Commun. 2021 Feb 10;12(1):920. doi: 10.1038/s41467-021-21159-7. Nat Commun. 2021. PMID: 33568647 Free PMC article.
20 results