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Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.
Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM. Turner N, et al. Among authors: james de. Diabetes. 2008 May;57(5):1414-8. doi: 10.2337/db07-1552. Epub 2008 Feb 19. Diabetes. 2008. PMID: 18285556
IRS1-independent defects define major nodes of insulin resistance.
Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y, James DE. Hoehn KL, et al. Among authors: james de. Cell Metab. 2008 May;7(5):421-33. doi: 10.1016/j.cmet.2008.04.005. Cell Metab. 2008. PMID: 18460333 Free PMC article.
Insulin resistance is a cellular antioxidant defense mechanism.
Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Hoehn KL, et al. Among authors: james de. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30. Proc Natl Acad Sci U S A. 2009. PMID: 19805130 Free PMC article.
395 results