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Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain.
Ahire C, Nyul-Toth A, DelFavero J, Gulej R, Faakye JA, Tarantini S, Kiss T, Kuan-Celarier A, Balasubramanian P, Ungvari A, Tarantini A, Nagaraja R, Yan F, Tang Q, Mukli P, Csipo T, Yabluchanskiy A, Campisi J, Ungvari Z, Csiszar A. Ahire C, et al. Among authors: faakye ja. Aging Cell. 2023 Jul;22(7):e13832. doi: 10.1111/acel.13832. Epub 2023 May 26. Aging Cell. 2023. PMID: 37243381 Free PMC article.
Imaging the time course, morphology, neuronal tissue compression, and resolution of cerebral microhemorrhages in mice using intravital two-photon microscopy: insights into arteriolar, capillary, and venular origin.
Faakye J, Nyúl-Tóth Á, Gulej R, Csik B, Tarantini S, Shanmugarama S, Prodan C, Mukli P, Yabluchanskiy A, Conley S, Toth P, Csiszar A, Ungvari Z. Faakye J, et al. Geroscience. 2023 Oct;45(5):2851-2872. doi: 10.1007/s11357-023-00839-w. Epub 2023 Jun 20. Geroscience. 2023. PMID: 37338779 Free PMC article.
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice.
Nyul-Toth A, Fulop GA, Tarantini S, Kiss T, Ahire C, Faakye JA, Ungvari A, Toth P, Toth A, Csiszar A, Ungvari Z. Nyul-Toth A, et al. Among authors: faakye ja. Geroscience. 2022 Apr;44(2):805-816. doi: 10.1007/s11357-021-00504-0. Epub 2022 Jan 6. Geroscience. 2022. PMID: 34989944 Free PMC article.
Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors.
Gulej R, Nyúl-Tóth Á, Csik B, Petersen B, Faakye J, Negri S, Chandragiri SS, Mukli P, Yabluchanskiy A, Conley S, Huffman DM, Csiszar A, Tarantini S, Ungvari Z. Gulej R, et al. Among authors: faakye j. Geroscience. 2024 Feb;46(1):327-347. doi: 10.1007/s11357-023-01039-2. Epub 2023 Dec 21. Geroscience. 2024. PMID: 38123890 Free PMC article.
Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype.
Gulej R, Csik B, Faakye J, Tarantini S, Shanmugarama S, Chandragiri SS, Mukli P, Conley S, Csiszar A, Ungvari Z, Yabluchanskiy A, Nyúl-Tóth Á. Gulej R, et al. Among authors: faakye j. Microcirculation. 2024 Feb;31(2):e12840. doi: 10.1111/micc.12840. Epub 2023 Dec 11. Microcirculation. 2024. PMID: 38082450
Temporary opening of the blood-brain barrier with the nitrone compound OKN-007.
Towner RA, Saunders D, Lerner M, Silasi Mansat R, Yuan T, Barber D, Faakye J, Nyul-Toth A, Csiszar A, Greenwood-Van Meerveld B, Smith N. Towner RA, et al. Among authors: faakye j. Am J Nucl Med Mol Imaging. 2021 Oct 15;11(5):363-373. eCollection 2021. Am J Nucl Med Mol Imaging. 2021. PMID: 34754607 Free PMC article.
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
Kiss T, Nyúl-Tóth Á, DelFavero J, Balasubramanian P, Tarantini S, Faakye J, Gulej R, Ahire C, Ungvari A, Yabluchanskiy A, Wiley G, Garman L, Ungvari Z, Csiszar A. Kiss T, et al. Among authors: faakye j. Geroscience. 2022 Apr;44(2):661-681. doi: 10.1007/s11357-022-00521-7. Epub 2022 Jan 31. Geroscience. 2022. PMID: 35098444 Free PMC article.