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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.
Gu F, Krüger A, Roggenkamp HG, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C LC, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao JY, Schetelig D, Werner R, Schröder K, Carty M, Bowie AG, Huber S, Meier C, Mittrücker HW, Heeren J, Krause KH, Flügel A, Diercks BP, Guse AH. Gu F, et al. Among authors: jaquet v. Sci Signal. 2021 Nov 16;14(709):eabe3800. doi: 10.1126/scisignal.abe3800. Epub 2021 Nov 16. Sci Signal. 2021. PMID: 34784249
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH, Bedard K. Jaquet V, et al. Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x. Br J Pharmacol. 2011. PMID: 21501142 Free PMC article.
NOX5: from basic biology to signaling and disease.
Bedard K, Jaquet V, Krause KH. Bedard K, et al. Among authors: jaquet v. Free Radic Biol Med. 2012 Feb 15;52(4):725-34. doi: 10.1016/j.freeradbiomed.2011.11.023. Epub 2011 Dec 14. Free Radic Biol Med. 2012. PMID: 22182486 Review.
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